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Gene Information
Gene symbol: BCKDHB
Gene name: branched chain keto acid dehydrogenase E1, beta polypeptide
HGNC ID: 987
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | EP300 | 1 hits |
| 2 | RB1 | 1 hits |
| 3 | TAF7 | 1 hits |
| 4 | TCF3 | 1 hits |
| 5 | TP53 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 14557644 | On the basis of the observation that the E1B 55kD gene product is able to bind to and inactivate p53, ONYX-015's mechanism of action is proposed to involve selective replication in and killing of p53-deficient cells. |
| 2 | 15826912 | However, mutant PAdV-3s containing deletion including authentic E1A promoter region, displayed both reduced steady-state levels of early gene mRNAs (E1A, E1B, E2A, E3, and E4) and decreased rate of viral replication in ST cells. |
| 3 | 16263418 | Our results demonstrate: 1) adenovirus infection of MCL cells despite the absence of receptor/coreceptor molecules known to be important for adenovirus infection of other cells types; 2) cytotoxicity of MCL cells after infection with specific adenovirus mutants; 3) a high degree of cytotoxicity after infection of some patient samples with viruses lacking the E1B 19k "antiapoptotic" gene; and 4) cytotoxicity after infection with viruses containing mutations in E1A pRb or p300 binding. |