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Gene Information
Gene symbol: BCL10
Gene name: B-cell CLL/lymphoma 10
HGNC ID: 989
Synonyms: CARMEN, CIPER, mE10, c-E10, CLAP
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CARD9 | 1 hits |
| 2 | CLEC4D | 1 hits |
| 3 | CLEC4E | 1 hits |
| 4 | CTLA4 | 1 hits |
| 5 | IL17C | 1 hits |
| 6 | IL1B | 1 hits |
| 7 | IL21 | 1 hits |
| 8 | JAGN1 | 1 hits |
| 9 | MALT1 | 1 hits |
| 10 | MAP3K14 | 1 hits |
| 11 | PGM3 | 1 hits |
| 12 | PIK3R1 | 1 hits |
| 13 | SYK | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 24806599 | Here we show that the coupling of ITAM-Syk-CARD9 signalling to interleukin-1 (IL-1) secretion in DCs is crucial for allergic sensitization to haptens. |
| 2 | 24806599 | Both MyD88 and Caspase recruitment domain-containing protein 9 (CARD9) signalling are required for contact hypersensitivity (CHS). |
| 3 | 24806599 | Naïve T cells require signals received through IL-1R1-MyD88 for effector differentiation, whereas DCs require CARD9 and spleen tyrosine kinase (Syk) signalling for hapten-induced IL-1α/β secretion and their ability to prime T cells. |
| 4 | 24806599 | DC-specific deletion of CARD9, DAP12, Syk or NLRP3, but not MyD88, is sufficient to abolish CHS. |
| 5 | 24806599 | All tested haptens, but not irritants, can induce Syk activation, leading to both the CARD9/BCL10-dependent pro-IL-1 synthesis (signal1) and reactive oxygen species-mediated NLRP3 inflammasome activation (signal2), required for IL-1 secretion. |
| 6 | 25202022 | C-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-κB activation. |
| 7 | 25202022 | Previous studies indicate that both Dectin-3 (also called MCL or Clec4d) and Mincle (also called Clec4e), two C-type lectin receptors, can recognize trehalose 6,6'-dimycolate (TDM), a cell wall component from mycobacteria, and induce potent innate immune responses. |
| 8 | 25956014 | New genes defects causing immunodeficiency include phophoglucomutase 3 (PGM3), cytidine 5' triphosphate synthase 1 (CTPS1), nuclear factor κB-inducing kinase (NIK), cytotoxic T lymphocyte-associated antigen 4 (CTLA4), B-cell chronic lymphocytic leukemia/lymphoma 10 (BCL10), phosphoinositide-3 kinase regulatory subunit 1 (PIK3R1), IL21, and Jagunal homolog 1 (JAGN1). |
| 9 | 25956014 | The role of IL-12 and IL-15 in the enhancement of natural killer cell activity was reported. |