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Gene Information
Gene symbol: BECN1
Gene name: beclin 1, autophagy related
HGNC ID: 1034
Synonyms: ATG6, VPS30
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATG3 | 1 hits |
| 2 | ATG5 | 1 hits |
| 3 | ATG7 | 1 hits |
| 4 | MAP1LC3A | 1 hits |
| 5 | SQSTM1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 22361584 | We observed that the knockdown of essential autophagy-related genes (ATG3, ATG5, ATG7 and BECN1) abolishes the pre-apoptotic secretion of ATP by several human and murine cancer cell lines undergoing ICD. |
| 2 | 22361584 | Cancer cell lines stably depleted of ATG5 or ATG7 normally generate tumors in vivo, and such autophagy-deficient neoplasms, upon systemic treatment with ICD inducers, exhibit the same levels of apoptosis (as monitored by nuclear shrinkage and caspase-3 activation) and necrosis (as determined by following the kinetics of HMGB1 release) as their autophagy-proficient counterparts. |
| 3 | 26424808 | We also find in PMNs an autophagic mechanism of bacterial killing based on the rapid induction of LC-3 conversion, beclin-1 expression, sequestosome 1 (SQSTM1) degradation and inhibition of bactericidal activity by the inhibitor, 3-methyladenine. |