Ignet

Gene Information

Gene symbol: BMP15

Gene name: bone morphogenetic protein 15

HGNC ID: 1068

Synonyms: GDF9B

Related Genes

#	Gene Symbol	Number of hits
1	GDF9	1 hits
2	OVGP1	1 hits
3	RPS27A	1 hits
4	TGFA	1 hits
5	TGFB1	1 hits
6	ZP3	1 hits

Related Sentences

#	PMID	Sentence
1	16737633	Currently, five different point mutations have been identified in the BMP15 (GDF9b) gene and one in GDF9.
2	16737633	Animals heterozygous for the GDF9 and/or the BMP15 mutations have higher ovulation rates than their wild-type counterparts.
3	16737633	In contrast, those homozygous for any of the aforementioned BMP15 or GDF9 mutations are sterile owing to arrested follicular development.
4	16737633	In bovine and ovine ovaries, GDF9 was expressed exclusively in oocytes throughout follicular growth from the primordial stage of development, whereas in sheep BMP15 was expressed exclusively in oocytes from the primary stage: no data for the ontogeny of BMP15 expression are currently available for cattle.
5	16737633	In vitro, ovine growth differentiation factor 9 (oGDF9) has no effect on (3)H-thymidine incorporation by either bovine or ovine granulosa cells, whereas ovine bone morphogenetic protein 15 (oBMP15) has modest (1.2- to 1.6-fold; P < 0.05) stimulatory effects.
6	16737633	Active immunisation of ewes with BMP15 and/or GDF9 peptides affected ovarian follicular development and ovulation rate.
7	16737633	Depending on the GDF9 and/or BMP15 vaccine formulation, ovulation rate was either increased or suppressed.
8	16737633	Currently, five different point mutations have been identified in the BMP15 (GDF9b) gene and one in GDF9.
9	16737633	Animals heterozygous for the GDF9 and/or the BMP15 mutations have higher ovulation rates than their wild-type counterparts.
10	16737633	In contrast, those homozygous for any of the aforementioned BMP15 or GDF9 mutations are sterile owing to arrested follicular development.
11	16737633	In bovine and ovine ovaries, GDF9 was expressed exclusively in oocytes throughout follicular growth from the primordial stage of development, whereas in sheep BMP15 was expressed exclusively in oocytes from the primary stage: no data for the ontogeny of BMP15 expression are currently available for cattle.
12	16737633	In vitro, ovine growth differentiation factor 9 (oGDF9) has no effect on (3)H-thymidine incorporation by either bovine or ovine granulosa cells, whereas ovine bone morphogenetic protein 15 (oBMP15) has modest (1.2- to 1.6-fold; P < 0.05) stimulatory effects.
13	16737633	Active immunisation of ewes with BMP15 and/or GDF9 peptides affected ovarian follicular development and ovulation rate.
14	16737633	Depending on the GDF9 and/or BMP15 vaccine formulation, ovulation rate was either increased or suppressed.
15	16737633	Currently, five different point mutations have been identified in the BMP15 (GDF9b) gene and one in GDF9.
16	16737633	Animals heterozygous for the GDF9 and/or the BMP15 mutations have higher ovulation rates than their wild-type counterparts.
17	16737633	In contrast, those homozygous for any of the aforementioned BMP15 or GDF9 mutations are sterile owing to arrested follicular development.
18	16737633	In bovine and ovine ovaries, GDF9 was expressed exclusively in oocytes throughout follicular growth from the primordial stage of development, whereas in sheep BMP15 was expressed exclusively in oocytes from the primary stage: no data for the ontogeny of BMP15 expression are currently available for cattle.
19	16737633	In vitro, ovine growth differentiation factor 9 (oGDF9) has no effect on (3)H-thymidine incorporation by either bovine or ovine granulosa cells, whereas ovine bone morphogenetic protein 15 (oBMP15) has modest (1.2- to 1.6-fold; P < 0.05) stimulatory effects.
20	16737633	Active immunisation of ewes with BMP15 and/or GDF9 peptides affected ovarian follicular development and ovulation rate.
21	16737633	Depending on the GDF9 and/or BMP15 vaccine formulation, ovulation rate was either increased or suppressed.
22	16737633	Currently, five different point mutations have been identified in the BMP15 (GDF9b) gene and one in GDF9.
23	16737633	Animals heterozygous for the GDF9 and/or the BMP15 mutations have higher ovulation rates than their wild-type counterparts.
24	16737633	In contrast, those homozygous for any of the aforementioned BMP15 or GDF9 mutations are sterile owing to arrested follicular development.
25	16737633	In bovine and ovine ovaries, GDF9 was expressed exclusively in oocytes throughout follicular growth from the primordial stage of development, whereas in sheep BMP15 was expressed exclusively in oocytes from the primary stage: no data for the ontogeny of BMP15 expression are currently available for cattle.
26	16737633	In vitro, ovine growth differentiation factor 9 (oGDF9) has no effect on (3)H-thymidine incorporation by either bovine or ovine granulosa cells, whereas ovine bone morphogenetic protein 15 (oBMP15) has modest (1.2- to 1.6-fold; P < 0.05) stimulatory effects.
27	16737633	Active immunisation of ewes with BMP15 and/or GDF9 peptides affected ovarian follicular development and ovulation rate.
28	16737633	Depending on the GDF9 and/or BMP15 vaccine formulation, ovulation rate was either increased or suppressed.
29	16737633	Currently, five different point mutations have been identified in the BMP15 (GDF9b) gene and one in GDF9.
30	16737633	Animals heterozygous for the GDF9 and/or the BMP15 mutations have higher ovulation rates than their wild-type counterparts.
31	16737633	In contrast, those homozygous for any of the aforementioned BMP15 or GDF9 mutations are sterile owing to arrested follicular development.
32	16737633	In bovine and ovine ovaries, GDF9 was expressed exclusively in oocytes throughout follicular growth from the primordial stage of development, whereas in sheep BMP15 was expressed exclusively in oocytes from the primary stage: no data for the ontogeny of BMP15 expression are currently available for cattle.
33	16737633	In vitro, ovine growth differentiation factor 9 (oGDF9) has no effect on (3)H-thymidine incorporation by either bovine or ovine granulosa cells, whereas ovine bone morphogenetic protein 15 (oBMP15) has modest (1.2- to 1.6-fold; P < 0.05) stimulatory effects.
34	16737633	Active immunisation of ewes with BMP15 and/or GDF9 peptides affected ovarian follicular development and ovulation rate.
35	16737633	Depending on the GDF9 and/or BMP15 vaccine formulation, ovulation rate was either increased or suppressed.
36	16737633	Currently, five different point mutations have been identified in the BMP15 (GDF9b) gene and one in GDF9.
37	16737633	Animals heterozygous for the GDF9 and/or the BMP15 mutations have higher ovulation rates than their wild-type counterparts.
38	16737633	In contrast, those homozygous for any of the aforementioned BMP15 or GDF9 mutations are sterile owing to arrested follicular development.
39	16737633	In bovine and ovine ovaries, GDF9 was expressed exclusively in oocytes throughout follicular growth from the primordial stage of development, whereas in sheep BMP15 was expressed exclusively in oocytes from the primary stage: no data for the ontogeny of BMP15 expression are currently available for cattle.
40	16737633	In vitro, ovine growth differentiation factor 9 (oGDF9) has no effect on (3)H-thymidine incorporation by either bovine or ovine granulosa cells, whereas ovine bone morphogenetic protein 15 (oBMP15) has modest (1.2- to 1.6-fold; P < 0.05) stimulatory effects.
41	16737633	Active immunisation of ewes with BMP15 and/or GDF9 peptides affected ovarian follicular development and ovulation rate.
42	16737633	Depending on the GDF9 and/or BMP15 vaccine formulation, ovulation rate was either increased or suppressed.
43	16737633	Currently, five different point mutations have been identified in the BMP15 (GDF9b) gene and one in GDF9.
44	16737633	Animals heterozygous for the GDF9 and/or the BMP15 mutations have higher ovulation rates than their wild-type counterparts.
45	16737633	In contrast, those homozygous for any of the aforementioned BMP15 or GDF9 mutations are sterile owing to arrested follicular development.
46	16737633	In bovine and ovine ovaries, GDF9 was expressed exclusively in oocytes throughout follicular growth from the primordial stage of development, whereas in sheep BMP15 was expressed exclusively in oocytes from the primary stage: no data for the ontogeny of BMP15 expression are currently available for cattle.
47	16737633	In vitro, ovine growth differentiation factor 9 (oGDF9) has no effect on (3)H-thymidine incorporation by either bovine or ovine granulosa cells, whereas ovine bone morphogenetic protein 15 (oBMP15) has modest (1.2- to 1.6-fold; P < 0.05) stimulatory effects.
48	16737633	Active immunisation of ewes with BMP15 and/or GDF9 peptides affected ovarian follicular development and ovulation rate.
49	16737633	Depending on the GDF9 and/or BMP15 vaccine formulation, ovulation rate was either increased or suppressed.
50	17070624	The antigens tested were bone morphogenic protein 15 (BMP15), oviduct glycoprotein (OGP) and ubiquitin-tagged mZP3.
51	17070624	This study found that when expressed by an MCMV vector, only full-length mZP3 or ubiquitin-tagged mZP3 induced infertility in female mice.
52	17070624	BMP15 and OGP had no effect.
53	17070624	The antigens tested were bone morphogenic protein 15 (BMP15), oviduct glycoprotein (OGP) and ubiquitin-tagged mZP3.
54	17070624	This study found that when expressed by an MCMV vector, only full-length mZP3 or ubiquitin-tagged mZP3 induced infertility in female mice.
55	17070624	BMP15 and OGP had no effect.
56	22106408	Active immunization against the proregions of GDF9 or BMP15 alters ovulation rate and litter size in mice.
57	22106408	The transforming growth factor β (TGFB) superfamily proteins bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9), are essential for mammalian fertility.
58	22106408	Recent in vitro evidence suggests that the proregions of mouse BMP15 and GDF9 interact with their mature proteins after secretion.
59	22106408	Mice were immunized with either N- or C-terminus proregion peptides of BMP15 or GDF9, or a full-length GDF9 proregion protein, each conjugated to keyhole limpet hemocyanin (KLH).
60	22106408	Antibody titers in sera increased throughout the study period, with no cross-reactivity observed between BMP15 and GDF9 sera and antigens.
61	22106408	These findings are consistent with the hypothesis that the proregions of BMP15 and GDF9, after secretion by the oocyte, have physiologically important roles in regulating ovulation rate and litter size in mice.
62	22106408	Active immunization against the proregions of GDF9 or BMP15 alters ovulation rate and litter size in mice.
63	22106408	The transforming growth factor β (TGFB) superfamily proteins bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9), are essential for mammalian fertility.
64	22106408	Recent in vitro evidence suggests that the proregions of mouse BMP15 and GDF9 interact with their mature proteins after secretion.
65	22106408	Mice were immunized with either N- or C-terminus proregion peptides of BMP15 or GDF9, or a full-length GDF9 proregion protein, each conjugated to keyhole limpet hemocyanin (KLH).
66	22106408	Antibody titers in sera increased throughout the study period, with no cross-reactivity observed between BMP15 and GDF9 sera and antigens.
67	22106408	These findings are consistent with the hypothesis that the proregions of BMP15 and GDF9, after secretion by the oocyte, have physiologically important roles in regulating ovulation rate and litter size in mice.
68	22106408	Active immunization against the proregions of GDF9 or BMP15 alters ovulation rate and litter size in mice.
69	22106408	The transforming growth factor β (TGFB) superfamily proteins bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9), are essential for mammalian fertility.
70	22106408	Recent in vitro evidence suggests that the proregions of mouse BMP15 and GDF9 interact with their mature proteins after secretion.
71	22106408	Mice were immunized with either N- or C-terminus proregion peptides of BMP15 or GDF9, or a full-length GDF9 proregion protein, each conjugated to keyhole limpet hemocyanin (KLH).
72	22106408	Antibody titers in sera increased throughout the study period, with no cross-reactivity observed between BMP15 and GDF9 sera and antigens.
73	22106408	These findings are consistent with the hypothesis that the proregions of BMP15 and GDF9, after secretion by the oocyte, have physiologically important roles in regulating ovulation rate and litter size in mice.
74	22106408	Active immunization against the proregions of GDF9 or BMP15 alters ovulation rate and litter size in mice.
75	22106408	The transforming growth factor β (TGFB) superfamily proteins bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9), are essential for mammalian fertility.
76	22106408	Recent in vitro evidence suggests that the proregions of mouse BMP15 and GDF9 interact with their mature proteins after secretion.
77	22106408	Mice were immunized with either N- or C-terminus proregion peptides of BMP15 or GDF9, or a full-length GDF9 proregion protein, each conjugated to keyhole limpet hemocyanin (KLH).
78	22106408	Antibody titers in sera increased throughout the study period, with no cross-reactivity observed between BMP15 and GDF9 sera and antigens.
79	22106408	These findings are consistent with the hypothesis that the proregions of BMP15 and GDF9, after secretion by the oocyte, have physiologically important roles in regulating ovulation rate and litter size in mice.
80	22106408	Active immunization against the proregions of GDF9 or BMP15 alters ovulation rate and litter size in mice.
81	22106408	The transforming growth factor β (TGFB) superfamily proteins bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9), are essential for mammalian fertility.
82	22106408	Recent in vitro evidence suggests that the proregions of mouse BMP15 and GDF9 interact with their mature proteins after secretion.
83	22106408	Mice were immunized with either N- or C-terminus proregion peptides of BMP15 or GDF9, or a full-length GDF9 proregion protein, each conjugated to keyhole limpet hemocyanin (KLH).
84	22106408	Antibody titers in sera increased throughout the study period, with no cross-reactivity observed between BMP15 and GDF9 sera and antigens.
85	22106408	These findings are consistent with the hypothesis that the proregions of BMP15 and GDF9, after secretion by the oocyte, have physiologically important roles in regulating ovulation rate and litter size in mice.
86	22106408	Active immunization against the proregions of GDF9 or BMP15 alters ovulation rate and litter size in mice.
87	22106408	The transforming growth factor β (TGFB) superfamily proteins bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9), are essential for mammalian fertility.
88	22106408	Recent in vitro evidence suggests that the proregions of mouse BMP15 and GDF9 interact with their mature proteins after secretion.
89	22106408	Mice were immunized with either N- or C-terminus proregion peptides of BMP15 or GDF9, or a full-length GDF9 proregion protein, each conjugated to keyhole limpet hemocyanin (KLH).
90	22106408	Antibody titers in sera increased throughout the study period, with no cross-reactivity observed between BMP15 and GDF9 sera and antigens.
91	22106408	These findings are consistent with the hypothesis that the proregions of BMP15 and GDF9, after secretion by the oocyte, have physiologically important roles in regulating ovulation rate and litter size in mice.