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Gene Information
Gene symbol: BRWD2
Gene name: bromodomain and WD repeat domain containing 2
HGNC ID: 13831
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | TERT | 1 hits |
| 3 | TNFRSF10A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 14581345 | We therefore sought to identify promiscuous Th epitopes in hTERT, which can be presented by more than one MHC class II allele. |
| 2 | 14581345 | Each of 10 peptides derived from hTERT that were predicted to bind to MHC class II molecules was found to be able to induce primary human T-cell responses in vitro. |
| 3 | 14581345 | We then established CD4(+) T-cell clones specific for these peptides and found that only hTERT(766) (LTDLQPYMRQFVAHL)-specific CD4(+) Th cells were effective in recognizing naturally processed hTERT antigen. |
| 4 | 14581345 | We further found that the naturally processed epitopes hTERT(766) and hTERT(672) (which was identified previously) were promiscuous and capable of inducing CD4(+) T-cell responses in the context of several commonly found HLA-DR alleles, including DR1, DR7, and DR15 for hTERT(672), and DR4, DR11, and DR15 for hTERT(766). |