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Gene Information
Gene symbol: BST2
Gene name: bone marrow stromal cell antigen 2
HGNC ID: 1119
Synonyms: CD317, tetherin
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ALCAM | 1 hits |
| 2 | CUL1 | 1 hits |
| 3 | FBXW10 | 1 hits |
| 4 | GPI | 1 hits |
| 5 | HLA-A | 1 hits |
| 6 | IFNGR1 | 1 hits |
| 7 | IGSF8 | 1 hits |
| 8 | KITLG | 1 hits |
| 9 | PARK2 | 1 hits |
| 10 | RPS27A | 1 hits |
| 11 | STAG2 | 1 hits |
| 12 | STX4 | 1 hits |
| 13 | TRIB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17238276 | For instance, the K5 modulator of immune recognition (MIR2) from Kaposi sarcoma-associated herpesvirus prevents activation of cytotoxic T cells, natural killer cells, and natural killer T cells by downregulating major histocompatibility complex (MHC) class I molecules, the MHC-like molecule CD1, the cell adhesion molecules ICAM-1 and PECAM, and the co-stimulatory molecule B7.2. |
| 2 | 17238276 | Mass spectrometric protein identification revealed four proteins that were consistently underrepresented in the plasma membrane of K5 expression cells: MHC I (as expected), bone marrow stromal antigen 2 (BST-2, CD316), activated leukocyte cell adhesion molecule (ALCAM, CD166) and Syntaxin-4. |
| 3 | 17238276 | Since ALCAM is the ligand for CD6, a member of the immunological synapse of T cells, its removal by viral immune modulators implies a role for CD6 in the recognition of pathogens by T cells. |
| 4 | 19605472 | K3/MIR1 and K5/MIR2 of Kaposi's sarcoma-associated herpesvirus (KSHV) are viral members of the membrane-associated RING-CH (MARCH) ubiquitin ligase family and contribute to viral immune evasion by directing the conjugation of ubiquitin to immunostimulatory transmembrane proteins. |
| 5 | 19605472 | Here we establish that despite its type II transmembrane topology and carboxy-terminal glycosylphosphatidylinositol (GPI) anchor, BST2 represents a bona fide target of K5 that is downregulated during primary infection by and reactivation of KSHV. |
| 6 | 19605472 | Ubiquitination of BST2 is required for degradation, since BST2 lacking cytosolic lysines was K5 resistant and ubiquitin depletion by proteasome inhibitors restored BST2 surface expression. |
| 7 | 19605472 | K3/MIR1 and K5/MIR2 of Kaposi's sarcoma-associated herpesvirus (KSHV) are viral members of the membrane-associated RING-CH (MARCH) ubiquitin ligase family and contribute to viral immune evasion by directing the conjugation of ubiquitin to immunostimulatory transmembrane proteins. |
| 8 | 19605472 | Here we establish that despite its type II transmembrane topology and carboxy-terminal glycosylphosphatidylinositol (GPI) anchor, BST2 represents a bona fide target of K5 that is downregulated during primary infection by and reactivation of KSHV. |
| 9 | 19605472 | Ubiquitination of BST2 is required for degradation, since BST2 lacking cytosolic lysines was K5 resistant and ubiquitin depletion by proteasome inhibitors restored BST2 surface expression. |
| 10 | 21674066 | Tetherin (BST-2/CD317) is an interferon-inducible antiviral protein that restricts the release of enveloped viruses from infected cells. |
| 11 | 22383521 | The HIV-1 accessory protein Vpu binds to both BST-2 and βTrCP, a substrate-recognition subunit for the SCF (Skip1-Cullin1-F-box protein) E3 ubiquitin ligase complex. |