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Gene Information
Gene symbol: BTK
Gene name: Bruton agammaglobulinemia tyrosine kinase
HGNC ID: 1133
Synonyms: ATK, XLA, PSCTK1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD19 | 1 hits |
| 2 | CD27 | 1 hits |
| 3 | FOXP3 | 1 hits |
| 4 | IBTK | 1 hits |
| 5 | IFNG | 1 hits |
| 6 | IL4 | 1 hits |
| 7 | PLCB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11877289 | We found HBenvAg-specific T lymphocytes producing interferon-gamma, interleukin-4, or both in the peripheral blood of XLA patients up to at least 24 months after completing the standard anti-HBV immunization protocol. |
| 2 | 11877289 | By combining cell purification and enzyme-linked immunospot assay, we found that effector CD27- T cells, which promptly produced cytokines in response to antigen (Ag), and memory-resting CD27+ T cells, which required Ag restimulation to perform their functions, were maintained in both XLA patients and controls for up to 24 months after the last vaccination boost. |
| 3 | 11877289 | We found HBenvAg-specific T lymphocytes producing interferon-gamma, interleukin-4, or both in the peripheral blood of XLA patients up to at least 24 months after completing the standard anti-HBV immunization protocol. |
| 4 | 11877289 | By combining cell purification and enzyme-linked immunospot assay, we found that effector CD27- T cells, which promptly produced cytokines in response to antigen (Ag), and memory-resting CD27+ T cells, which required Ag restimulation to perform their functions, were maintained in both XLA patients and controls for up to 24 months after the last vaccination boost. |
| 5 | 23719297 | In vitro coincubation of B cells with plasma from CML patients on TKI or with imatinib, dasatinib, or nilotinib induced significant and dose-dependent inhibition of Bruton's tyrosine kinase and indirectly its downstream substrate, phospholipase-C-γ2, both important in B-cell signaling and survival. |
| 6 | 24569953 | Classically utilized to enumerate lymphocyte subsets, flow cytometric-based assays are increasingly utilized to test immune cell function (e.g., neutrophil oxidative burst, NK cytotoxicity), intracellular cytokine production (e.g., TH17 production), cellular signaling pathways (e.g., phosphor-STAT analysis), and protein expression (e.g., BTK, Foxp3). |
| 7 | 25900577 | X-linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by marked reduction in all classes of serum immunoglobulins and the near absence of mature CD19(+) B-cells. |
| 8 | 24157582 | Ibrutinib, an inhibitor of Bruton's tyrosine kinase is showing impressive responses in heavily pre-treated high-risk CLL, whether alone or in combination with MoAbs or chemotherapy. |