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Gene Information
Gene symbol: CARM1
Gene name: coactivator-associated arginine methyltransferase 1
HGNC ID: 23393
Synonyms: PRMT4
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | PRMT1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16648481 | Although some family members, PRMT1 and PRMT4, have been implicated in transcriptional modulation or intracellular signaling, the roles of other PRMTs in diverse cellular processes have not been fully established. |
| 2 | 16648481 | Here, we report that PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis. |
| 3 | 16648481 | PRMT2 exerted this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. |
| 4 | 16648481 | PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB. |
| 5 | 16648481 | Mouse embryo fibroblasts from PRMT2 genetic knockouts showed elevated NF-kappaB activity and decreased susceptibility to apoptosis compared to wild-type or complemented cells. |
| 6 | 16648481 | Taken together, these data suggest that PRMT2 inhibits cell activation and promotes programmed cell death through this NF-kappaB-dependent mechanism. |