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Gene Information
Gene symbol: CASP7
Gene name: caspase 7, apoptosis-related cysteine peptidase
HGNC ID: 1508
Synonyms: MCH3, CMH-1, ICE-LAP3
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | APAF1 | 1 hits |
| 2 | CASP3 | 1 hits |
| 3 | CASP9 | 1 hits |
| 4 | DFFA | 1 hits |
| 5 | DFFB | 1 hits |
| 6 | PARP1 | 1 hits |
| 7 | RHOD | 1 hits |
| 8 | ROCK1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 22249285 | We report that hepatitis B vaccine exposure resulted in significant upregulation of the key genes encoding caspase 7, caspase 9, Inhibitor caspase-activated DNase (ICAD), Rho-associated coiled-coil containing protein kinase 1 (ROCK-1), and Apoptotic protease activating factor 1 (Apaf-1). |
| 2 | 22249285 | Upregulation of cleaved caspase 3,7 were detected by western blot in addition to Apaf-1 and caspase 9 expressions argues that cell death takes place via the intrinsic apoptotic pathway in which release of cytochrome c from the mitochondria triggers the assembly of a caspase activation complex. |
| 3 | 26101550 | The mechanism of action is shown to be related to the buildup of abasic sites that cause PARP activation and PARP cleavage, and the activation of caspase-3 and caspase-7, which is consistent with cell death by apoptosis. |