Ignet

Gene Information

Gene symbol: CAT

Gene name: catalase

HGNC ID: 1516

Related Genes

#	Gene Symbol	Number of hits
1	AKT1	1 hits
2	ALB	1 hits
3	DDX53	1 hits
4	DPP4	1 hits
5	GSR	1 hits
6	HBB	1 hits
7	HSPD1	1 hits
8	IFNG	1 hits
9	IL1B	1 hits
10	IL2	1 hits
11	IV	1 hits
12	KRAS	1 hits
13	MAPK1	1 hits
14	MPO	1 hits
15	MUC1	1 hits
16	NFKB1	1 hits
17	PRDX6	1 hits
18	PSMD9	1 hits
19	SOD1	1 hits
20	TDO2	1 hits

Related Sentences

#	PMID	Sentence
1	1344009	Effect of oxygen intermediates (OI) scavengers such as superoxide dismutase and catalase on Salmonella-killing activity of activated macrophages was not seen at all.
2	6826236	This stimulation of cytotoxicity can be partially inhibited by catalase and the combination of superoxide dismutase plus catalase.
3	6940467	Effects of interferon-inducing agents on hepatic cytochrome P-450 drug metabolizing systems.
4	6940467	The loss of cytochrome P-450 elicited by IF-inducing agents is accompanied by a perturbation of heme metabolism associated with the dissociation of heme from cytochrome P-450.
5	6940467	The agents also cause losses of hepatic catalase and tryptophan 2,3-dioxygenase.
6	7130393	The specific activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and myeloperoxidase, and the specific content of glutathione were not diminished in LK-treated MDM, suggesting that increased synthesis of H(2)O(2) rather than decreased catabolism probably explained the greater release of H(2)O(2) from LK-treated cells.
7	7228389	Addition of sodium azide, N-ethylmaleimide, superoxide dismutase, or catalase to the CL reaction mixture containing PMN from infected animals significantly decreased the CL response.
8	7271064	During this incubation there was stimulation of the granulocyte chemiluminescence, which was proportional to the virus dose, prevented by treatment with cytochalasin B, and reduced by catalase and sodium benzoate but not by superoxide dismutase.
9	8027551	IL-10, TGF-beta 1, and IFN-alpha (cytokines known to regulate effector functions of activated macrophages) also did not block anti-F. tularensis activity of IFN-gamma-stimulated AM.
10	8027551	Reactive oxygen metabolites, depletion of tryptophan, and sequestration of iron did not contribute to anti-F. tularensis activity because addition of superoxide dismutase or catalase, excess iron, or tryptophan to IFN-gamma-treated AM did not reverse the anti-F. tularensis activity observed in these cells.
11	8988394	These include adhesins, cytotoxins and a range of different enzymes including urease, catalase and superoxide dismutase.
12	9587254	Mycobacterium bovis BCG (strain 1173P2) was grown in Middlebrook (M) 7H9 broth containing albumin-dextrose-catalase and 0.05% tween 80, and transformed BCG was grown in M7H10 agar containing kanamycin for counting viable cells.
13	9682400	Intracellular levels of superoxide dismutase and catalase were very low in the beginning.
14	10069962	Replicon vector C20DX2Arep, containing a unique cloning site followed by the sequence of 2A autoprotease of foot-and-mouth disease virus, was constructed and used for expression of a number of heterologous genes including chloramphenicol acetyltransferase (CAT), green fluorescent protein (GFP), beta-galactosidase, glycoprotein G of vesicular stomatitis virus, and the Core and NS3 genes of hepatitis C virus.
15	12393638	In healthy individuals, a positive lymphoproliferative response was documented to cellular extracts of A fumigatus (14 of 16), the 88-kDa dipeptidylpeptidase (4 of 16), and the 90-kDa catalase (8 of 11).
16	12393638	In patients with clinical evidence of invasive aspergillosis, a favorable response to antifungal therapy was found to correlate with a higher IFN-gamma/interleukin 10 (IL-10) ratio in culture supernatants (n = 7; median ratio, IFN-gamma/IL-10 = 1.0; range, 0.09-24.8) compared to 10 patients with progressive or stable disease (median ratio, IFN-gamma/IL-10 = 0.1; range, 0.002-2.1; P =.04).
17	12393638	In contrast to cytomegalovirus- and tetanus toxoid-specific T-cell responses, Aspergillus-specific T-cell reconstitution late after allogeneic SCT was characterized by low stimulation indices and a low IFN-gamma/IL-10 ratio.
18	12919752	Active proteins such as GFP, CAT, and SIV p27 were expressed within infected cells.
19	15289022	Using a similar protocol, we generated murine cytokine activated T lymphocytes (CAT) from splenocytes with the sequential addition of IFN-gamma, IL-1beta, anti-CD3 and IL-2.
20	15845483	Experiments then compared experimental dental caries after immunization with SYI-CAT, SYI, or CAT MAP constructs, followed by infection with Streptococcus mutans strain SJr.
21	16386858	Interestingly, Trp-P-1-inhibited proliferation in the splenocytes was restored almost completely by N-acetyl-l-cysteine (NAC) and partially by glutathione (GSH), whereas no effect was found when superoxide dismutase and catalase were used.
22	16614935	Over-expression of CAGE enhanced growth rates, promoted cell motility and led to an ROS scavenging effect which was accompanied by an induced catalase cavity.
23	16614935	Further, peptides of CAGE induced cytolytic T lymphocytes (CTL) activity, and CD8+ T cells pre-sensitized with these peptides displayed cytotoxic effects against cancer cells expressing CAGE.
24	16790773	Streptolysin O treatment of infected human macrophages indicated that catalase-peroxidase and the heat shock protein GroEL are released intracellularly by actively growing F. tularensis.
25	16790773	Mice immunized with F. tularensis developed significant cell-mediated immune responses to catalase-peroxidase, the heat shock protein GroEL, and bacterioferritin as measured by splenic lymphocyte proliferation and gamma interferon production.
26	16790773	Streptolysin O treatment of infected human macrophages indicated that catalase-peroxidase and the heat shock protein GroEL are released intracellularly by actively growing F. tularensis.
27	16790773	Mice immunized with F. tularensis developed significant cell-mediated immune responses to catalase-peroxidase, the heat shock protein GroEL, and bacterioferritin as measured by splenic lymphocyte proliferation and gamma interferon production.
28	17338375	Due to oxidase and catalase activities, the microorganisms induced the denaturation of hemoglobin (Hb) through RBC oxidation to H2O2 in high concentration providing the formation of haemin and transformation of haem Fe2+ into the utilizable form, Fe3+.
29	19917753	We found that Francisella sp. growing in broth culture or within human macrophages can acquire Fe from the two major host Fe-binding proteins, lactoferrin (Lf) and transferrin (Tf).
30	19917753	Francisella spp. express two Fe-containing antioxidant enzymes, catalase (KatG) and Fe cofactored superoxide dismutase (FeSOD).
31	20093115	In Fasciola species, peroxiredoxin (Prx) serves as the major antioxidant enzyme to remove hydrogen peroxide that is generated from various metabolic reactions, because the parasites lack catalase, and only express glutathione peroxidases at minimal levels.
32	20558723	SchuS4 infection also blocked signals required for macrophage cytokine production, including Akt phosphorylation, IkappaB alpha degradation, and NF-kappaB nuclear localization and activation.
33	20558723	Mutation of catalase (katG) sensitized F. tularensis to H(2)O(2) and enhanced PTEN oxidation, Akt phosphorylation, NF-kappaB activation, and inflammatory cytokine production.
34	23084846	The H. pylori antioxidant enzymes superoxide dismutase (SOD) and catalase (KatA) have been shown to be protective as vaccine antigens in mice, demonstrating that the organism's antioxidant enzyme system is a fruitful target for vaccine development.
35	24599827	The oxidative stress markers (malondialdehyde and carbonyl derivatives of protein oxidative destruction levels), antioxidant defenses (superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase), and total antioxidant capacity in different tissues of rainbow trout were measured.
36	25725402	Superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT) activities in mucus and skin, along with the SOD, POD and CAT mRNA expression in skin significantly decreased at day 4 and 6, indicating the decreased antioxidant capacity of the challenged fish.
37	26195933	The open forum discussion session allowed for a direct interaction between ATMP developers and the speakers from EMA and CAT.
38	26374215	Marketing Regulatory Oversight of Advanced Therapy Medicinal Products (ATMPs) in Europe: The EMA/CAT Perspective.
39	26374215	Technical requirements for ATMPs are defined in the legislation, and guidance for different products is available through several EMA/CAT guidelines.
40	26374215	Marketing Regulatory Oversight of Advanced Therapy Medicinal Products (ATMPs) in Europe: The EMA/CAT Perspective.
41	26374215	Technical requirements for ATMPs are defined in the legislation, and guidance for different products is available through several EMA/CAT guidelines.