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Gene Information
Gene symbol: CBFB
Gene name: core-binding factor, beta subunit
HGNC ID: 1539
Synonyms: PEBP2B
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | RUNX1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 9188573 | Within the U3 repeats, the major determinant of T-cell specificity has been mapped to binding sites for the AML1 transcription factor family (also known as the core binding factor [CBF], polyomavirus enhancer binding protein 2 [PEBP2], and SL3-3 enhancer factor 1 [SEF-1]). |
| 2 | 9188573 | Moreover, proviruses were found to be integrated at the c-myc locus in similar proportions of wild-type and mutant SL3-3-induced tumors, and the mutated AML1 sites of proviruses at c-myc are unaltered. |
| 3 | 9188573 | In some cases, however, including one c-myc-integrated provirus, a single-base pair change was detected in a second, weaker AML1 binding site. |
| 4 | 9188573 | By DNA rearrangement analysis of the T-cell receptor beta-locus, tumors induced by the AML1 site mutants are found to be of the T-cell type. |
| 5 | 9188573 | Thus, although the AML1 site mutants have weakened T-cell-specific enhancers they are T-lymphomagenic, and wild-type- and mutant-virus-induced tumor DNAs are similar with respect to the number of overall ecotropic and c-myc-integrated clonal proviruses. |