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Gene Information
Gene symbol: CBL
Gene name: Cbl proto-oncogene, E3 ubiquitin protein ligase
HGNC ID: 1541
Synonyms: RNF55, c-Cbl
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | CBLB | 1 hits |
| 3 | CD40 | 1 hits |
| 4 | IL12A | 1 hits |
| 5 | MAPK1 | 1 hits |
| 6 | MAPK6 | 1 hits |
| 7 | PIK3CA | 1 hits |
| 8 | RPS27A | 1 hits |
| 9 | SCYL1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21799517 | In c-Cbl-deficient dendritic cells, Toll-like receptor-induced expression of proinflammatory factors, such as interleukin-12, is increased, correlating with a greater potency of dendritic-cell-based vaccines against established tumours. |
| 2 | 21799517 | In addition, c-Cbl deficiency reduces both p50 and p105 levels, which have been shown to modulate the stimulatory function of NF-κB. |
| 3 | 21799517 | In c-Cbl-deficient dendritic cells, Toll-like receptor-induced expression of proinflammatory factors, such as interleukin-12, is increased, correlating with a greater potency of dendritic-cell-based vaccines against established tumours. |
| 4 | 21799517 | In addition, c-Cbl deficiency reduces both p50 and p105 levels, which have been shown to modulate the stimulatory function of NF-κB. |
| 5 | 23762309 | Cbl proteins are E3 ubiquitin ligases and have been implicated in regulating the functional activity of various immune cells. |
| 6 | 23762309 | Upon TLR-stimulation, cblb-/- BMDCs produce higher levels of proinflammatory cytokines (IL-1α, IL-6 and TNF-α) and exhibit a slightly higher level of FITC-dextran uptake. |
| 7 | 23762309 | To further characterize the functional significance of cblb-/- BMDCs we tested them in antigen-specific T cell responses against ovalbumin (OVA) protein and peptides, activating either CD8(+) OT-I or CD4(+) OT-II transgenic T cells. |
| 8 | 23762309 | We conclude that in contrast to c-Cbl, Cbl-b plays only a limited role in the induction of Ag-specific T cell responses by murine BMDCs in vitro and in vivo. |
| 9 | 23762309 | Cbl proteins are E3 ubiquitin ligases and have been implicated in regulating the functional activity of various immune cells. |
| 10 | 23762309 | Upon TLR-stimulation, cblb-/- BMDCs produce higher levels of proinflammatory cytokines (IL-1α, IL-6 and TNF-α) and exhibit a slightly higher level of FITC-dextran uptake. |
| 11 | 23762309 | To further characterize the functional significance of cblb-/- BMDCs we tested them in antigen-specific T cell responses against ovalbumin (OVA) protein and peptides, activating either CD8(+) OT-I or CD4(+) OT-II transgenic T cells. |
| 12 | 23762309 | We conclude that in contrast to c-Cbl, Cbl-b plays only a limited role in the induction of Ag-specific T cell responses by murine BMDCs in vitro and in vivo. |
| 13 | 25680514 | The DEX (CRCL-GL261)-DCs were found to promote cell proliferation and cytotoxic T lymphocyte (CTL) activity of CD4(+) and CD8(+) T cells in vitro compared with DEX (GL261)-DCs, which were loaded with DEXs derived from DCs loaded with GL261 tumor cell lysates. |
| 14 | 25680514 | Moreover, depletion of CD4(+) and CD8(+) T cells significantly impaired the anti-tumor effect of DEX (CRCL-GL261)-DCs. |
| 15 | 25680514 | Finally, DEX (CRCL-GL261)-DCs were found to negatively regulate Casitas B cell lineage lymphoma (Cbl)-b and c-Cbl signaling, leading to the activation of phosphatidyl inositol 3-kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK) signaling in T cells. |