Ignet

Gene Information

Gene symbol: CBLB

Gene name: Cbl proto-oncogene, E3 ubiquitin protein ligase B

HGNC ID: 1542

Synonyms: RNF56, Cbl-b

Related Genes

#	Gene Symbol	Number of hits
1	ATM	1 hits
2	CBL	1 hits
3	CD8A	1 hits
4	IL2	1 hits
5	RNF123	1 hits
6	UBR5	1 hits

Related Sentences

#	PMID	Sentence
1	21383769	Reinforcement of cancer immunotherapy by adoptive transfer of cblb-deficient CD8+ T cells combined with a DC vaccine.
2	21383769	The E3 ubiquitin ligase Cbl-b is a key regulator of T cell activation and is established to regulate TGF-β sensitivity. cblb-deficient animals reject tumors via CD8(+) T cells, which make Cbl-b an ideal target for improvement of adoptive T-cell transfer (ATC) therapy.
3	21383769	In this study, we show that cblb-deficient CD8(+) T cells are hyper-responsive to T-cell receptor (TCR)/CD28-stimulation and are in part protected against the negative cues induced by TGF-β in vitro.
4	21383769	Thus, cblb-deficient ATC requires proper in vivo re-activation by a dendritic cell (DC) vaccine.
5	21383769	Reinforcement of cancer immunotherapy by adoptive transfer of cblb-deficient CD8+ T cells combined with a DC vaccine.
6	21383769	The E3 ubiquitin ligase Cbl-b is a key regulator of T cell activation and is established to regulate TGF-β sensitivity. cblb-deficient animals reject tumors via CD8(+) T cells, which make Cbl-b an ideal target for improvement of adoptive T-cell transfer (ATC) therapy.
7	21383769	In this study, we show that cblb-deficient CD8(+) T cells are hyper-responsive to T-cell receptor (TCR)/CD28-stimulation and are in part protected against the negative cues induced by TGF-β in vitro.
8	21383769	Thus, cblb-deficient ATC requires proper in vivo re-activation by a dendritic cell (DC) vaccine.
9	22962608	Adoptive transfer of siRNA Cblb-silenced CD8+ T lymphocytes augments tumor vaccine efficacy in a B16 melanoma model.
10	22962608	The ubiquitin ligase Cbl-b is an established regulator of T cell immune response thresholds.
11	22962608	Importantly, CBLB silencing in human CD8(+) T cells mirrored the effects observed for cblb-silenced and cblb-deficient murine T cells.
12	22962608	Adoptive transfer of siRNA Cblb-silenced CD8+ T lymphocytes augments tumor vaccine efficacy in a B16 melanoma model.
13	22962608	The ubiquitin ligase Cbl-b is an established regulator of T cell immune response thresholds.
14	22962608	Importantly, CBLB silencing in human CD8(+) T cells mirrored the effects observed for cblb-silenced and cblb-deficient murine T cells.
15	22962608	Adoptive transfer of siRNA Cblb-silenced CD8+ T lymphocytes augments tumor vaccine efficacy in a B16 melanoma model.
16	22962608	The ubiquitin ligase Cbl-b is an established regulator of T cell immune response thresholds.
17	22962608	Importantly, CBLB silencing in human CD8(+) T cells mirrored the effects observed for cblb-silenced and cblb-deficient murine T cells.
18	23762309	Cbl proteins are E3 ubiquitin ligases and have been implicated in regulating the functional activity of various immune cells.
19	23762309	Upon TLR-stimulation, cblb-/- BMDCs produce higher levels of proinflammatory cytokines (IL-1α, IL-6 and TNF-α) and exhibit a slightly higher level of FITC-dextran uptake.
20	23762309	To further characterize the functional significance of cblb-/- BMDCs we tested them in antigen-specific T cell responses against ovalbumin (OVA) protein and peptides, activating either CD8(+) OT-I or CD4(+) OT-II transgenic T cells.
21	23762309	We conclude that in contrast to c-Cbl, Cbl-b plays only a limited role in the induction of Ag-specific T cell responses by murine BMDCs in vitro and in vivo.
22	25597949	Short exposure to AFB1 suppressed innate immune transcripts, especially from antimicrobial genes, but increased the expression of transcripts from E3 ubiquitin-protein ligase CBL-B and multiple interleukin-2 response genes.
23	25597949	Up-regulation of transcripts from lymphotactin, granzyme A, and perforin 1 could indicate either increased cytotoxic potential or activation-induced cell death in the spleen during aflatoxicosis.