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Gene Information
Gene symbol: CCND2
Gene name: cyclin D2
HGNC ID: 1583
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CDKN1B | 1 hits |
| 2 | LGALS1 | 1 hits |
| 3 | LGALS2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11434720 | Specifically, anergy is characterized by lack of activation of lck, ZAP 70, Ras, ERK, JNK, AP-1, and NF-AT. |
| 2 | 11434720 | This second messenger upregulates the cyclin-dependent kinase (cdk) inhibitor p27kip1, sequestering cyclin D2-cdk4, and cyclin E/cdk2 complexes and preventing progression of T cells through the G1 restriction point of the cell cycle. |
| 3 | 11434720 | In contrast, costimulation through CD28 prevents p27kip1 accumulation by decreasing the levels of intracellular cAMP and promotes p27kip1 down-regulation due to direct degradation of the protein via the ubiquitin-proteasome pathway. |
| 4 | 11434720 | Subsequent autocrine action of IL-2 leads to further degradation of p27kip1 and entry into S phase. |
| 5 | 19155521 | Additionally, there was up-regulation of probesets associated with cytotoxic (GZMB, TNFSF10) and regulatory (INDO, CTLA4) activities. |
| 6 | 19155521 | The strongest correlations with neutralizing Ab titers were found for cyclin D2 (CCND2) and galectin (LGALS2). |