Ignet

Gene Information

Gene symbol: CCR3

Gene name: chemokine (C-C motif) receptor 3

HGNC ID: 1604

Synonyms: CC-CKR-3, CKR3, CD193

Related Genes

#	Gene Symbol	Number of hits
1	CCL11	1 hits
2	CCL28	1 hits
3	CCL3	1 hits
4	CCR1	1 hits
5	CCR10	1 hits
6	CCR2	1 hits
7	CCR5	1 hits
8	CCR8	1 hits
9	CCR9	1 hits
10	CD19	1 hits
11	CD4	1 hits
12	CXCR4	1 hits
13	CXCR6	1 hits
14	GPR15	1 hits

Related Sentences

#	PMID	Sentence
1	10064617	A functional, discontinuous HIV-1 gp120 C3/C4 domain-derived, branched, synthetic peptide that binds to CD4 and inhibits MIP-1alpha chemokine binding.
2	10064617	The peptide incorporates elements of both the conserved CD4 and CCR5 binding sites.
3	10064617	When preincubated with the CD4+ve MM6 macrophage cell line, which expresses mRNA for the CCR3 and CCR5 chemokine receptors, both 3.7 and gp120 inhibit binding of the chemokine MIP-1alpha.
4	11242524	Cloning and sequencing of cynomolgus macaque CCR3, GPR15, and STRL33: potential coreceptors for HIV type 1, HIV type 2, and SIV.
5	11242524	However, since it is known that minor species-specific sequence changes in CCR3 and STRL33 affect their ability to act as coreceptors for HIV-1, HIV-2, and/or SIV, it is important to ascertain whether the relevant receptors function as expected in the animal model of choice.
6	11242524	The sequence of three cynomolgus macaque receptors, CCR3, GPR15, and STRL33, are presented in this sequence note.
7	11242524	Cloning and sequencing of cynomolgus macaque CCR3, GPR15, and STRL33: potential coreceptors for HIV type 1, HIV type 2, and SIV.
8	11242524	However, since it is known that minor species-specific sequence changes in CCR3 and STRL33 affect their ability to act as coreceptors for HIV-1, HIV-2, and/or SIV, it is important to ascertain whether the relevant receptors function as expected in the animal model of choice.
9	11242524	The sequence of three cynomolgus macaque receptors, CCR3, GPR15, and STRL33, are presented in this sequence note.
10	11242524	Cloning and sequencing of cynomolgus macaque CCR3, GPR15, and STRL33: potential coreceptors for HIV type 1, HIV type 2, and SIV.
11	11242524	However, since it is known that minor species-specific sequence changes in CCR3 and STRL33 affect their ability to act as coreceptors for HIV-1, HIV-2, and/or SIV, it is important to ascertain whether the relevant receptors function as expected in the animal model of choice.
12	11242524	The sequence of three cynomolgus macaque receptors, CCR3, GPR15, and STRL33, are presented in this sequence note.
13	11333875	We also tested this clone for its ability to use the chemokine receptors CCR1, CCR2b, CCR3, CXCR4, and CCR5 and found that the clone utilizes only CCR5 as the coreceptor for cell entry.
14	14581570	Nine Envs used CCR5 as a coreceptor, one used CXCR4, and two used both CCR5 and CXCR4 in cell-to-cell fusion assays.
15	14581570	Eight Envs could also use CCR3, CCR8, GPR15, STRL33, Apj, and/or GPR1, but these coreceptors did not play a major role in virus entry into microglia.
16	15122808	Other recombinant chemokines (MIP-1alpha/CCL3, MIP-1beta/CCL4, MCP-2/CCL8, eotaxin/CCL11, MIP-1delta/CCL15, stromal cell derived factor (SDF)-1alpha/CXCL12) were not inhibitory.
17	15122808	Flow cytometry further revealed that epithelial cells were positive for CCR3, but not CCR1 or CCR5.
18	15996192	Few Ig+ cells expressed CCR2, CCR3, or CCR9, and there was no difference in the expression of these receptors between IgA+ and IgG+ cells.
19	15996192	In contrast, CCR4, CCR5, and CXCR3 was expressed on significantly more IgG+ than IgA+ cells.
20	15996192	IgG+ memory cells migrated to a higher extent than IgA+ cells towards the CXCR3 ligand CXCL11/I-TAC, while there was only a small migration towards the CCR4 ligand CCL17/TARC and the CCR9 ligand CCL25/TECK.
21	15996192	In conclusion, this study shows that IgG+ and IgA+ memory B cells have a differential expression of the Th1 associated chemokine receptor CXCR3, as well as of CCR4 and CCR5.
22	20810746	The data showed that the majority of T/F Envs used CCR5 and that many also used CCR3, although less efficiently.
23	22066023	Mucosae-associated epithelial chemokine (MEC or CCL28) binds to CCR3 and CCR10 and recruits IgA-secreting plasma cells (IgA-ASCs) in the mucosal lamina propria.
24	22066023	Mice receiving either HIV-1(IIIB) VLPs alone, CCL28 alone, or the irrelevant CCL19 chemokine were used as controls.
25	22066023	Results showed a significantly increased CCR3 and CCR10 expression on CD19(+) splenocytes of HIV-1(IIIB) VPL-CCL28-treated mice.
26	22066023	HIV-1 Env-specific IFN-γ, IL-4 and IL-5 production, total IgA, anti-Env IgA as well as gastro-intestinal mucosal IgA-secreting plasma cells were also significantly augmented in these mice.
27	22066023	Mucosae-associated epithelial chemokine (MEC or CCL28) binds to CCR3 and CCR10 and recruits IgA-secreting plasma cells (IgA-ASCs) in the mucosal lamina propria.
28	22066023	Mice receiving either HIV-1(IIIB) VLPs alone, CCL28 alone, or the irrelevant CCL19 chemokine were used as controls.
29	22066023	Results showed a significantly increased CCR3 and CCR10 expression on CD19(+) splenocytes of HIV-1(IIIB) VPL-CCL28-treated mice.
30	22066023	HIV-1 Env-specific IFN-γ, IL-4 and IL-5 production, total IgA, anti-Env IgA as well as gastro-intestinal mucosal IgA-secreting plasma cells were also significantly augmented in these mice.
31	25135831	Additionally, active atypical and active classical MBC expressed higher levels of eotaxin receptor CCR3 than the other B cell subsets, suggesting a chemotactic effect of eotaxin on these B cell subsets.