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Gene Information
Gene symbol: CDC2
Gene name: cell division cycle 2, G1 to S and G2 to M
HGNC ID: 1722
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCNB1 | 1 hits |
| 2 | CCNK | 1 hits |
| 3 | CDC25C | 1 hits |
| 4 | CDK2 | 1 hits |
| 5 | CDK4 | 1 hits |
| 6 | CDK6 | 1 hits |
| 7 | CDK9 | 1 hits |
| 8 | FOXM1 | 1 hits |
| 9 | MAP2K3 | 1 hits |
| 10 | PLK1 | 1 hits |
| 11 | TP53 | 1 hits |
| 12 | WEE1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20023695 | The Ras oncogene is known to activate three major MAPK pathways, ERK, JNK, p38 and exert distinct cellular phenotypes, that is, apoptosis and invasion through the Ras-MKK3-p38-signaling cascade. |
| 2 | 20023695 | Stable transfection of NIH3T3 fibroblasts with MKK3(act) cDNA construct revealed similar p38-dependent in vitro characteristics observed in Ha-Ras(EJ)-transformed NIH3T3 cells, including enhanced invasiveness and anchorage-independent growth correlating with p38 phosphorylation status. |
| 3 | 20023695 | Using this phenotype-assisted approach combined with system level protein-interaction network analysis, we identified FOXM1, PLK1 and CDK1 to be differentially regulated in invasive Ha-Ras(EJ)-NIH3T3 and MKK3(act)-NIH3T3 cells. |
| 4 | 21525341 | We then showed that the activity of the Cdc2-cyclin B1 complex was significantly decreased in HHV-6A-infected HSB-2 cells. |
| 5 | 21525341 | Furthermore, we found that inactivation of Cdc2-cyclin B1 in HHV-6A-infected cells occurred through the inhibitory Tyr15 phosphorylation resulting from elevated Wee1 expression and inactivated Cdc25C. |
| 6 | 21525341 | The reduction of Cdc2-cyclin B1 activity in HHV-6-infected cells was also partly due to the increased expression of the cell cycle-regulatory molecule p21 in a p53-dependent manner. |
| 7 | 21525341 | In addition, HHV-6A infection activated the DNA damage checkpoint kinases Chk2 and Chk1. |
| 8 | 21525341 | We then showed that the activity of the Cdc2-cyclin B1 complex was significantly decreased in HHV-6A-infected HSB-2 cells. |
| 9 | 21525341 | Furthermore, we found that inactivation of Cdc2-cyclin B1 in HHV-6A-infected cells occurred through the inhibitory Tyr15 phosphorylation resulting from elevated Wee1 expression and inactivated Cdc25C. |
| 10 | 21525341 | The reduction of Cdc2-cyclin B1 activity in HHV-6-infected cells was also partly due to the increased expression of the cell cycle-regulatory molecule p21 in a p53-dependent manner. |
| 11 | 21525341 | In addition, HHV-6A infection activated the DNA damage checkpoint kinases Chk2 and Chk1. |
| 12 | 21525341 | We then showed that the activity of the Cdc2-cyclin B1 complex was significantly decreased in HHV-6A-infected HSB-2 cells. |
| 13 | 21525341 | Furthermore, we found that inactivation of Cdc2-cyclin B1 in HHV-6A-infected cells occurred through the inhibitory Tyr15 phosphorylation resulting from elevated Wee1 expression and inactivated Cdc25C. |
| 14 | 21525341 | The reduction of Cdc2-cyclin B1 activity in HHV-6-infected cells was also partly due to the increased expression of the cell cycle-regulatory molecule p21 in a p53-dependent manner. |
| 15 | 21525341 | In addition, HHV-6A infection activated the DNA damage checkpoint kinases Chk2 and Chk1. |
| 16 | 22723289 | The Eimeria tenella CDC2-related kinase 2 (EtCRK2) is a validated drug target that can be activated in vitro by the CDK activator XlRINGO (Xenopus laevis rapid inducer of G2/M progression in oocytes). |
| 17 | 24695529 | However, we show that the KSHV v-cyclin (K-cyclin), which utilizes different CDK partners (CDK4 and CDK6) than the MHV68 v-cyclin (CDK2 and CDC2), can partially rescue the replication defect observed with a v-cyclin null mutant--both in vitro and in vivo. |