Ignet

Gene Information

Gene symbol: CDK5R1

Gene name: cyclin-dependent kinase 5, regulatory subunit 1 (p35)

HGNC ID: 1775

Synonyms: p35nck5a, Nck5a

Related Genes

#	Gene Symbol	Number of hits
1	ALK	1 hits
2	ATM	1 hits
3	CD200	1 hits
4	CD37	1 hits
5	CD53	1 hits
6	CD63	1 hits
7	CD81	1 hits
8	CD9	1 hits
9	CDKN1A	1 hits
10	CDKN2A	1 hits
11	DDX5	1 hits
12	MAPK1	1 hits
13	PTGES3	1 hits
14	TSPAN8	1 hits

Related Sentences

#	PMID	Sentence
1	1281197	To date there are 13 members including ME491 (CD63, Pltgp40), CD9 (p23), TAPA-1, CD37, CD53, MRC OX-44, CO-029, MRP-1, L6, the gene product of TI-1, the target of mAb AD-1, SM23, and SJ23 (the Schistosoma japonicum homologue).
2	10683917	SDS-PAGE showed that the molecular weights of expression proteins were 68 kd and 23 kd respectively, designated p68 and p23.
3	10683917	Purifying and isolating p68 and p23, we separated them from SDS-Polyacrylamide gels by using Side-Strip method.
4	10683917	After fragmenting and electroeluting, p68 and p23 were injected into guinea pigs and rabbits.
5	10683917	The results of improved MTT and conA 3HTdR transformation methods showed the activities and proliferation of Th-cells were increased in guinea pigs after p68 immunization (IL-6, 83.25 IU/ml, IL-2, 28.75 IU/ml; RPI, 2.04, SI, 65.62%) Thlymphocyte existed in two subclasses, the Th1- and Th2-cells.
6	10683917	SDS-PAGE showed that the molecular weights of expression proteins were 68 kd and 23 kd respectively, designated p68 and p23.
7	10683917	Purifying and isolating p68 and p23, we separated them from SDS-Polyacrylamide gels by using Side-Strip method.
8	10683917	After fragmenting and electroeluting, p68 and p23 were injected into guinea pigs and rabbits.
9	10683917	The results of improved MTT and conA 3HTdR transformation methods showed the activities and proliferation of Th-cells were increased in guinea pigs after p68 immunization (IL-6, 83.25 IU/ml, IL-2, 28.75 IU/ml; RPI, 2.04, SI, 65.62%) Thlymphocyte existed in two subclasses, the Th1- and Th2-cells.
10	10683917	SDS-PAGE showed that the molecular weights of expression proteins were 68 kd and 23 kd respectively, designated p68 and p23.
11	10683917	Purifying and isolating p68 and p23, we separated them from SDS-Polyacrylamide gels by using Side-Strip method.
12	10683917	After fragmenting and electroeluting, p68 and p23 were injected into guinea pigs and rabbits.
13	10683917	The results of improved MTT and conA 3HTdR transformation methods showed the activities and proliferation of Th-cells were increased in guinea pigs after p68 immunization (IL-6, 83.25 IU/ml, IL-2, 28.75 IU/ml; RPI, 2.04, SI, 65.62%) Thlymphocyte existed in two subclasses, the Th1- and Th2-cells.
14	12083770	Two proteins with 21 (p21) and 23 kDa (p23) were detected in immunoblot with a serum from a chronic carrier patient, as the major products for HCcAg.
15	12083770	Both proteins, p21 and p23, produced by proteolytic processing in P. partoris, share the same N-terminal region and reacted with a monoclonal antibody towards the first 35 amino acids of HCcAg.
16	12083770	Two proteins with 21 (p21) and 23 kDa (p23) were detected in immunoblot with a serum from a chronic carrier patient, as the major products for HCcAg.
17	12083770	Both proteins, p21 and p23, produced by proteolytic processing in P. partoris, share the same N-terminal region and reacted with a monoclonal antibody towards the first 35 amino acids of HCcAg.
18	21336991	The molecular weight (23 kDa) and immunogenicity of p23 gene expressed by L. casei Zhang were similar to that of the native P23 protein.
19	21336991	Furthermore, the expression of cytokines such as IL-4, IL-6, and IFN-γ in splenocytes of mice was detected by real-time PCR after oral immunization.
20	23460736	The ataxia telangiectasia mutated kinase pathway regulates IL-23 expression by human dendritic cells.
21	23460736	In this study, we show for first time, to our knowledge, that the ataxia telangiectasia mutated (ATM) pathway, involved in DNA damage sensing, acts as an IL-23 repressor.
22	23460736	Inhibition of ATM with the highly selective antagonist KU55933 markedly increased IL-23 secretion in human monocyte-derived DC and freshly isolated myeloid DC.
23	23460736	Priming naive CD4(+) T cells with ATM-inhibited DC increased Th17 responses over and above those obtained with mature DC.
24	23460736	Although ATM blockade increased the abundance of p19, p35, and p40 mRNA, IL-12p70 secretion was unaffected.
25	23460736	To further examine a role for ATM in IL-23 regulation, we exposed DC to low doses of ionizing radiation.
26	23460736	Exposure of DC to x-rays resulted in ATM phosphorylation and a corresponding depression of IL-23.
27	23460736	Importantly, ATM inhibition with KU55933 prevented radiation-induced ATM phosphorylation and abrogated the capacity of x-rays to suppress IL-23.
28	23460736	To explore how ATM repressed IL-23, we examined a role for endoplasmic reticulum stress responses by measuring generation of the spliced form of X-box protein-1, a key endoplasmic reticulum stress transcription factor.
29	23460736	Inhibition of ATM increased the abundance of X-box protein-1 mRNA, and this was followed 3 h later by increased peak p19 transcription and IL-23 release.
30	23460736	In summary, ATM activation or inhibition, respectively, inhibited or augmented IL-23 release.
31	23696342	Since the initial discovery of ALK as an oncogenic tyrosine kinase involved in the chromosomal translocation t(2, 5)(p23;q35) in 1994, more than 20 translocation partners of ALK have been identified in various cancers.
32	24796351	Co-expression of a viral RNA silencing suppressor, p23 or p19, in N. benthamiana resulted in earlier accumulation and increased production (15-25%) of target protein (influenza virus hemagglutinin).