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Gene Information
Gene symbol: CDKN1C
Gene name: cyclin-dependent kinase inhibitor 1C (p57, Kip2)
HGNC ID: 1786
Synonyms: P57, KIP2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BCL2L11 | 1 hits |
| 2 | CREBBP | 1 hits |
| 3 | MIRN221 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 26090579 | IFN-α-Induced Downregulation of miR-221 in Dendritic Cells: Implications for HCV Pathogenesis and Treatment. |
| 2 | 26090579 | We report that IFN-α downregulates miR-221 in both DC subsets via inhibition of STAT3. |
| 3 | 26090579 | We validated proapoptotic proteins BCL2L11 and CDKN1C as miR-221 targets suggesting that IFN-α can induce DC apoptosis via miR-221 downregulation. |
| 4 | 26090579 | In addition, we validated another miR-221 target, SOCS1, which is known to be a negative regulator of JAK/STAT signaling. |
| 5 | 26090579 | Consistent with this, miR-221 overexpression in mDCs enhanced the secretion of proinflammatory cytokines IL-6 and TNF-α. |
| 6 | 26090579 | In peripheral blood mononuclear cells (PBMCs) of HIV-1/HCV co-infected individuals undergoing IFN-α-based treatment the baseline miR-221 expression was lower in non-responders compared with responders; and miR-221 expression directly correlated with DC frequency and IL-6/TNF-α secretion. |
| 7 | 26337545 | The main aim of this cross-sectional study was to evaluate immunization coverage and the timeliness of vaccination in children suffering from 3 different rare genetic diseases: Rubinstein-Taybi syndrome (RSTS), Sotos syndrome (SS), and Beckwith-Wiedemann syndrome (BWS). |
| 8 | 26337545 | This study shows that vaccination coverage is poor in pediatric patients with RSTS, BWS, and SS and significantly lower than that observed in healthy children. |
| 9 | 26337545 | The main aim of this cross-sectional study was to evaluate immunization coverage and the timeliness of vaccination in children suffering from 3 different rare genetic diseases: Rubinstein-Taybi syndrome (RSTS), Sotos syndrome (SS), and Beckwith-Wiedemann syndrome (BWS). |
| 10 | 26337545 | This study shows that vaccination coverage is poor in pediatric patients with RSTS, BWS, and SS and significantly lower than that observed in healthy children. |