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Gene Information
Gene symbol: CHI3L1
Gene name: chitinase 3-like 1 (cartilage glycoprotein-39)
HGNC ID: 1932
Synonyms: GP39, YKL40
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IL6 | 1 hits |
| 2 | TP53 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17285289 | Vaccination with p53 peptide-pulsed dendritic cells is associated with disease stabilization in patients with p53 expressing advanced breast cancer; monitoring of serum YKL-40 and IL-6 as response biomarkers. |
| 2 | 17285289 | This was supported by: (1) a positive correlation between p53 expression of tumor and observed SD, (2) therapy induced p53 specific T cells in 4/7 patients with SD but only in 2/9 patients with PD, and (3) significant response associated changes in serum YKL-40 and IL-6 levels identifying these biomarkers as possible candidates for monitoring of response in connection with DC based cancer immunotherapy. |
| 3 | 17285289 | Vaccination with p53 peptide-pulsed dendritic cells is associated with disease stabilization in patients with p53 expressing advanced breast cancer; monitoring of serum YKL-40 and IL-6 as response biomarkers. |
| 4 | 17285289 | This was supported by: (1) a positive correlation between p53 expression of tumor and observed SD, (2) therapy induced p53 specific T cells in 4/7 patients with SD but only in 2/9 patients with PD, and (3) significant response associated changes in serum YKL-40 and IL-6 levels identifying these biomarkers as possible candidates for monitoring of response in connection with DC based cancer immunotherapy. |
| 5 | 18779742 | Twenty-seven patients with progressive cytokine-refractory metastatic renal cell carcinoma were vaccinated with DCs loaded with either a cocktail of survivin and telomerase peptides or tumor lysate depending on their HLA-A2 haplotype, and low-dose IL-2 was administered concomitantly. |
| 6 | 18779742 | Tumor response, immune response, and serum IL-6 and YKL-40 were measured during treatment. |
| 7 | 18779742 | Furthermore, significant alterations in serum YKL-40 and IL-6 were found during treatment. |
| 8 | 18779742 | Twenty-seven patients with progressive cytokine-refractory metastatic renal cell carcinoma were vaccinated with DCs loaded with either a cocktail of survivin and telomerase peptides or tumor lysate depending on their HLA-A2 haplotype, and low-dose IL-2 was administered concomitantly. |
| 9 | 18779742 | Tumor response, immune response, and serum IL-6 and YKL-40 were measured during treatment. |
| 10 | 18779742 | Furthermore, significant alterations in serum YKL-40 and IL-6 were found during treatment. |