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Gene Information
Gene symbol: CLDN7
Gene name: claudin 7
HGNC ID: 2049
Synonyms: Hs.84359
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCL2 | 1 hits |
| 2 | CD81 | 1 hits |
| 3 | CLDN1 | 1 hits |
| 4 | EGFR | 1 hits |
| 5 | LDLR | 1 hits |
| 6 | OCLN | 1 hits |
| 7 | RHOD | 1 hits |
| 8 | SCARB1 | 1 hits |
| 9 | TJP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18579606 | Combining confocal microscopy with biochemical analysis and studies of infection requirements using pharmacological inhibitors and small interfering RNAs, we show here that engagement of CD81 activates the Rho GTPase family members Rac, Rho, and Cdc42 and that the block of these signaling pathways drastically reduces HCV infectivity. |
| 2 | 18579606 | Activation of Rho GTPases mediates actin-dependent relocalization of the HCV E2/CD81 complex to cell-cell contact areas where CD81 comes into contact with the tight-junction proteins occludin, ZO-1, and claudin-1, which was recently described as an HCV coreceptor. |
| 3 | 19273272 | These include CD81, highly sulfated heparan sulfate, the low-density lipoprotein receptor, scavenger receptor class B type I and claudin-1. |
| 4 | 21734774 | Despite the recent discovery of the tight junction-associated proteins claudin-1 and occludin as HCV co-receptors, which is an important step towards the understanding of HCV entry, the precise mechanisms are still largely unknown. |
| 5 | 23429668 | HCV entry is a complex multistep process involving multiple cell cofactors (glycosaminoglycans, low density lipoprotein receptor, SR-B1, CD81, claudin-1, occludin, EGFR, EphA2) in the interaction with HCV E1/E2 envelope glycoproteins. |
| 6 | 26277777 | Identification of CCL2, RARRES2 and EFNB2 as host cell factors that influence the multistep replication of respiratory syncytial virus. |
| 7 | 26277777 | Among the genes identified, chemokine (C-C motif) ligand 2 (CCL2), retinoic acid receptor responder protein 2 (RARRES2) and ephrin-B2 (EFNB2) had a positive effect on RSV replication. |
| 8 | 26277777 | CCL2 expression also disrupted the distribution of claudin-1, a tight junction protein, suggesting that CCL2 plays a role in claudin-based tight junction formation during RSV replication. |
| 9 | 26277777 | The knockdown of EFNB2 and RARRES2 by siRNA in RSV-susceptible cell lines (HEp-2 and A549) resulted in reduced RSV replication, suggesting that EFNB2 and RARRES2 participate in RSV replication. |
| 10 | 26277777 | Together, our findings suggest that CCL2, RARRES2 and EFNB2 are host cell factors involved in RSV replication. |