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Gene Information
Gene symbol: CLEC4C
Gene name: C-type lectin domain family 4, member C
HGNC ID: 13258
Synonyms: HECL, DLEC, BDCA2, CD303
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AHR | 1 hits |
| 2 | CD1C | 1 hits |
| 3 | CD207 | 1 hits |
| 4 | CD209 | 1 hits |
| 5 | CD34 | 1 hits |
| 6 | CD4 | 1 hits |
| 7 | ITGAX | 1 hits |
| 8 | LAMP3 | 1 hits |
| 9 | NRP1 | 1 hits |
| 10 | PDC | 1 hits |
| 11 | THBD | 1 hits |
| 12 | TLR8 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19049809 | In this study, we report a novel direct ex vivo 11-color flow cytometric assay that combines subset identification with analysis of activation status and endocytic ability of three major PBDC subsets (CD1c(+)CD11c(+) "MDC1," CD141(+)CD11c(+) "MDC2," and CD303(+)CD11c(-) "PDC") within a single platform. |
| 2 | 19049809 | As expected, PBDC identified by this assay express low levels of CD40 and CD86 directly ex vivo, and significantly upregulate expression of these molecules upon stimulation with toll-like receptor ligands LPS and CpG oligonucleotides. |
| 3 | 19049809 | In addition, PDC internalize FITC-labeled dextran poorly in comparison to MDC1 and MDC2 subsets. |
| 4 | 19049809 | Furthermore, the combination of surface markers used in this assay reveals a previously unreported CD4(+)CD11c(+)CD303(-)CD1c(-)CD141(-) cell population. |
| 5 | 21439318 | Positive and double staining for CD11c and BDCA-2, pDC/IPC, DC-LAMP, DC-SIGN, TLR8 and Langerin have been observed revealing new mouse intestinal DC subsets. |
| 6 | 24325394 | The aryl hydrocarbon receptor antagonist StemRegenin 1 promotes human plasmacytoid and myeloid dendritic cell development from CD34+ hematopoietic progenitor cells. |
| 7 | 24325394 | Here, we show that by inhibiting the aryl hydrocarbon receptor with its antagonist StemRegenin 1 (SR1), clinical-scale numbers of functional BDCA2(+)BDCA4(+) pDCs, BDCA1(+) mDCs, and BDCA3(+)DNGR1(+) mDCs can be efficiently generated from human CD34(+) HPCs. |
| 8 | 24325394 | They secreted high levels of pro-inflammatory cytokines such as interferon (IFN)-α, interleukin (IL)-12, and tumor necrosis factor (TNF)-α and upregulated co-stimulatory molecules and maturation markers following stimulation with Toll-like receptor (TLR) ligands. |
| 9 | 24999737 | Examination of various myeloid (CD11c+CD303-) and plasmacytoid (CD11c-CD303+) DC populations in the peripheral blood of seasonal trivalent inactivated influenza vaccine recipients revealed a transient decrease in the frequency of CD11c+CD1c- myeloid DC subsets 5-10 days following vaccination, including both CD141+ and CD141- myeloid DC subsets of this population. |