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Gene Information

Gene symbol: CLEC6A

Gene name: C-type lectin domain family 6, member A

HGNC ID: 14556

Synonyms: dectin-2

Related Genes

#	Gene Symbol	Number of hits
1	CD209	1 hits
2	CD4	1 hits
3	CD8A	1 hits
4	CLEC4D	1 hits
5	CLEC4E	1 hits
6	CLEC7A	1 hits
7	CTAG1B	1 hits
8	IL12A	1 hits
9	LGALS3	1 hits
10	MAGEA1	1 hits
11	MRC1	1 hits

Related Sentences

#	PMID	Sentence
1	16781694	Induction of CD8+ T cell responses through targeting of antigen to Dectin-2.
2	16781694	We investigated whether the efficacy with which immune responses are induced can be improved by targeting Ags to a C-type lectin receptor, Dectin-2.
3	16781694	Ag conjugated to anti-Dectin-2 mAbs was presented efficiently to CD8+ T cells in vivo and elicited CD8+ T cell responses at low doses where free Ag failed to induce a response.
4	16781694	Induction of CD8+ T cell responses through targeting of antigen to Dectin-2.
5	16781694	We investigated whether the efficacy with which immune responses are induced can be improved by targeting Ags to a C-type lectin receptor, Dectin-2.
6	16781694	Ag conjugated to anti-Dectin-2 mAbs was presented efficiently to CD8+ T cells in vivo and elicited CD8+ T cell responses at low doses where free Ag failed to induce a response.
7	16781694	Induction of CD8+ T cell responses through targeting of antigen to Dectin-2.
8	16781694	We investigated whether the efficacy with which immune responses are induced can be improved by targeting Ags to a C-type lectin receptor, Dectin-2.
9	16781694	Ag conjugated to anti-Dectin-2 mAbs was presented efficiently to CD8+ T cells in vivo and elicited CD8+ T cell responses at low doses where free Ag failed to induce a response.
10	17959670	Immunization with a lentivector that targets tumor antigen expression to dendritic cells induces potent CD8+ and CD4+ T-cell responses.
11	17959670	A dectin-2 lentivector encoding the human melanoma antigen NY-ESO-1 primed an NY-ESO-1-specific CD8(+) T-cell response in HLA-A2 transgenic mice and stimulated a CD4(+) T-cell response to a newly identified NY-ESO-1 epitope presented by H2 I-A(b).
12	24135577	The vaccine, human papillomavirus peptides with Candida, demonstrated partial maturation effects on Langerhans cells indicated by significantly up-regulated CD40 (p=0.00007) and CD80 (p<0.00001) levels, and showed T-cell proliferative capacity (p<0.00001) when presented by Langerhans cells in vitro.
13	24135577	The cytokine profile (IL-1β, IL-6, IL-8, IL-10, IL-12p40, IL-23Ap19, IFN-γ and TNF-α) of Langerhans cells treated with the vaccine or Candida alone showed that IL-12p40 mRNA was most frequently induced, and IL-12p70 protein was detected in the supernatants.
14	24135577	The presence of pattern recognition receptors known to associate with Candida albicans (DC-SIGN, dectin-1, dectin-2, galectin-3, mincle, mannose receptor, Toll-like receptors-1, 2, 4, 6 and 9) were demonstrated in all subjects.
15	24205278	These results suggest that the detection of PPV antigens via Dectin-2 triggers IL-12 production, which induces IFN-γ synthesis by NKT cells and subsequently the production of serotype-specific IgG.
16	24391211	Acquired immunity to B. dermatitidis requires Dectin-2, whereas vaccination against H. capsulatum and C. posadasii infection depends on innate sensing by Dectin-1 and Dectin-2, but not Mincle.