Ignet

Gene Information

Gene symbol: CLPB

Gene name: ClpB caseinolytic peptidase B homolog (E. coli)

HGNC ID: 30664

Synonyms: HSP78, SKD3, FLJ13152

Related Genes

#	Gene Symbol	Number of hits
1	CPX	1 hits
2	GLDN	1 hits
3	HSPA1A	1 hits
4	HSPD1	1 hits
5	IDH3B	1 hits
6	IL17A	1 hits
7	TLR2	1 hits

Related Sentences

#	PMID	Sentence
1	10231014	Co-immunoprecipitation and Western blot studies show that hsp27, hsp70, and hsp78 complex with HIV-1 viral proteins intracellularly.
2	10231014	Hsp70, hsp56, and CypA are assembled into HIV-1 virions.
3	15892173	Globally, 36 different proteins were identified, which strongly reacted with sera from experimentally infected mice, including several putative virulence markers of intracellular pathogens as nucleoside diphosphate kinase, isocitrate dehydrogenase, RNA-binding protein Hfq, and molecular chaperone ClpB.
4	21988354	These include outer membrane protein OmpA (P60), trigger factor, ClpB, elongation factor G, gliding motility protein GldN and a conserved hypothetical protein.
5	23529616	LVS clpB provoked a robust adaptive immune response similar in magnitude to that provoked by LVS but with increased gamma interferon (IFN-γ) and interleukin-17A (IL-17A) production, as measured by mean fluorescence intensity.
6	24236032	Previously, we developed a novel live vaccine strain, by deleting the chaperonin clpB gene from F. tularensis subsp. tularensis strain, SCHU S4.
7	25201075	Interestingly, LipL45, ClpA and ClpB, exhibiting obvious amino acid mutations among str.56601, str.JDL03 and JDL10, might contribute to virulence differences observed among these strains.
8	25250027	TLR2 Signaling is Required for the Innate, but Not Adaptive Response to LVS clpB.
9	25250027	We sought to determine whether TLR2 signaling was required during the immune response to LVS clpB.
10	25250027	TLR2 knock-out (TLR2 KO) mice previously infected with LVS clpB are completely protected during a lethal challenge with LVS.
11	25250027	Furthermore, the kinetics and magnitude of the primary T-cell response in B6 and TLR2 KO mice are similar indicating that TLR2 signaling is dispensable for the adaptive immune response to LVS clpB.
12	25250027	TLR2 signaling was important, however, for the innate immune response to LVS clpB.
13	25250027	IL-1α, IL-1β, IL-2, IL-17, MIP-1α, and TNF-α production depended on TLR2 signaling, while GM-CSF, IFN-γ, and VEGF production were completely independent of TLR2 signaling.
14	25250027	IL-6, IL-12, IP-10, KC, and MIG production were partially dependent on TLR2 signaling.
15	25250027	Together our data indicate that the innate immune response to LVS clpB requires TLR2 signaling for the maximal innate response, whereas TLR2 is not required for the adaptive immune response.
16	25250027	TLR2 Signaling is Required for the Innate, but Not Adaptive Response to LVS clpB.
17	25250027	We sought to determine whether TLR2 signaling was required during the immune response to LVS clpB.
18	25250027	TLR2 knock-out (TLR2 KO) mice previously infected with LVS clpB are completely protected during a lethal challenge with LVS.
19	25250027	Furthermore, the kinetics and magnitude of the primary T-cell response in B6 and TLR2 KO mice are similar indicating that TLR2 signaling is dispensable for the adaptive immune response to LVS clpB.
20	25250027	TLR2 signaling was important, however, for the innate immune response to LVS clpB.
21	25250027	IL-1α, IL-1β, IL-2, IL-17, MIP-1α, and TNF-α production depended on TLR2 signaling, while GM-CSF, IFN-γ, and VEGF production were completely independent of TLR2 signaling.
22	25250027	IL-6, IL-12, IP-10, KC, and MIG production were partially dependent on TLR2 signaling.
23	25250027	Together our data indicate that the innate immune response to LVS clpB requires TLR2 signaling for the maximal innate response, whereas TLR2 is not required for the adaptive immune response.
24	25250027	TLR2 Signaling is Required for the Innate, but Not Adaptive Response to LVS clpB.
25	25250027	We sought to determine whether TLR2 signaling was required during the immune response to LVS clpB.
26	25250027	TLR2 knock-out (TLR2 KO) mice previously infected with LVS clpB are completely protected during a lethal challenge with LVS.
27	25250027	Furthermore, the kinetics and magnitude of the primary T-cell response in B6 and TLR2 KO mice are similar indicating that TLR2 signaling is dispensable for the adaptive immune response to LVS clpB.
28	25250027	TLR2 signaling was important, however, for the innate immune response to LVS clpB.
29	25250027	IL-1α, IL-1β, IL-2, IL-17, MIP-1α, and TNF-α production depended on TLR2 signaling, while GM-CSF, IFN-γ, and VEGF production were completely independent of TLR2 signaling.
30	25250027	IL-6, IL-12, IP-10, KC, and MIG production were partially dependent on TLR2 signaling.
31	25250027	Together our data indicate that the innate immune response to LVS clpB requires TLR2 signaling for the maximal innate response, whereas TLR2 is not required for the adaptive immune response.
32	25250027	TLR2 Signaling is Required for the Innate, but Not Adaptive Response to LVS clpB.
33	25250027	We sought to determine whether TLR2 signaling was required during the immune response to LVS clpB.
34	25250027	TLR2 knock-out (TLR2 KO) mice previously infected with LVS clpB are completely protected during a lethal challenge with LVS.
35	25250027	Furthermore, the kinetics and magnitude of the primary T-cell response in B6 and TLR2 KO mice are similar indicating that TLR2 signaling is dispensable for the adaptive immune response to LVS clpB.
36	25250027	TLR2 signaling was important, however, for the innate immune response to LVS clpB.
37	25250027	IL-1α, IL-1β, IL-2, IL-17, MIP-1α, and TNF-α production depended on TLR2 signaling, while GM-CSF, IFN-γ, and VEGF production were completely independent of TLR2 signaling.
38	25250027	IL-6, IL-12, IP-10, KC, and MIG production were partially dependent on TLR2 signaling.
39	25250027	Together our data indicate that the innate immune response to LVS clpB requires TLR2 signaling for the maximal innate response, whereas TLR2 is not required for the adaptive immune response.
40	25250027	TLR2 Signaling is Required for the Innate, but Not Adaptive Response to LVS clpB.
41	25250027	We sought to determine whether TLR2 signaling was required during the immune response to LVS clpB.
42	25250027	TLR2 knock-out (TLR2 KO) mice previously infected with LVS clpB are completely protected during a lethal challenge with LVS.
43	25250027	Furthermore, the kinetics and magnitude of the primary T-cell response in B6 and TLR2 KO mice are similar indicating that TLR2 signaling is dispensable for the adaptive immune response to LVS clpB.
44	25250027	TLR2 signaling was important, however, for the innate immune response to LVS clpB.
45	25250027	IL-1α, IL-1β, IL-2, IL-17, MIP-1α, and TNF-α production depended on TLR2 signaling, while GM-CSF, IFN-γ, and VEGF production were completely independent of TLR2 signaling.
46	25250027	IL-6, IL-12, IP-10, KC, and MIG production were partially dependent on TLR2 signaling.
47	25250027	Together our data indicate that the innate immune response to LVS clpB requires TLR2 signaling for the maximal innate response, whereas TLR2 is not required for the adaptive immune response.
48	25250027	TLR2 Signaling is Required for the Innate, but Not Adaptive Response to LVS clpB.
49	25250027	We sought to determine whether TLR2 signaling was required during the immune response to LVS clpB.
50	25250027	TLR2 knock-out (TLR2 KO) mice previously infected with LVS clpB are completely protected during a lethal challenge with LVS.
51	25250027	Furthermore, the kinetics and magnitude of the primary T-cell response in B6 and TLR2 KO mice are similar indicating that TLR2 signaling is dispensable for the adaptive immune response to LVS clpB.
52	25250027	TLR2 signaling was important, however, for the innate immune response to LVS clpB.
53	25250027	IL-1α, IL-1β, IL-2, IL-17, MIP-1α, and TNF-α production depended on TLR2 signaling, while GM-CSF, IFN-γ, and VEGF production were completely independent of TLR2 signaling.
54	25250027	IL-6, IL-12, IP-10, KC, and MIG production were partially dependent on TLR2 signaling.
55	25250027	Together our data indicate that the innate immune response to LVS clpB requires TLR2 signaling for the maximal innate response, whereas TLR2 is not required for the adaptive immune response.