Ignet

Gene Information

Gene symbol: COL2A1

Gene name: collagen, type II, alpha 1

HGNC ID: 2200

Related Genes

#	Gene Symbol	Number of hits
1	CD4	1 hits
2	CD40	1 hits
3	CD80	1 hits
4	CD86	1 hits
5	COL1A1	1 hits
6	IL4	1 hits
7	TGFB1	1 hits

Related Sentences

#	PMID	Sentence
1	11282981	Known determinants were introduced into chondrocytes of transgenic (TG) mice, under the control of the cis-regulatory sequences of the human type II collagen gene (COL2A1).
2	18684965	Vaccination without autoantigen protects against collagen II-induced arthritis via immune deviation and regulatory T cells.
3	18684965	A Salmonella vector expressing colonization factor Ag I (CFA/I), shown to behave as an anti-inflammatory vaccine, stimulates the production of CD4(+)CD25(+) T cells and regulatory cytokines.
4	18684965	In this work, we queried whether Salmonella-CFA/I can protect DBA/1 mice from collagen-induced arthritis.
5	18684965	Clinical findings were accompanied by the suppression of inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-27.
6	18684965	Vaccination evoked a multi-tier response consisting of IL-4 producing Th2 cells, an increased production of TGF-beta by CD4(+) T cells, and suppression of collagen II-specific CD4(+) T cell proliferation.
7	18684965	To assess the contribution of Salmonella-CFA/I-primed CD4(+) T cells, adoptive transfer studies with total CD4(+), CD4(+)CD25(-), or CD4(+)CD25(+) T cells were performed 15 days postchallenge.
8	18684965	Mice receiving either subset showed reduced disease incidence and low clinical scores; however, mice receiving total CD4(+) T cells showed delayed disease onset by 10 days with reduced clinical scores, reduced IL-17 and IL-27, but enhanced IL-4, IL-10, IL-13, and TGF-beta.
9	18684965	Inhibition of TGF-beta or IL-4 compromised protective immunity.
10	18684965	These data show that Salmonella-CFA/I vaccination of DBA/1 mice protects against collagen-induced arthritis by stimulating TGF-beta- and IL-4-producing regulatory CD4(+) T cells.
11	18684965	Vaccination without autoantigen protects against collagen II-induced arthritis via immune deviation and regulatory T cells.
12	18684965	A Salmonella vector expressing colonization factor Ag I (CFA/I), shown to behave as an anti-inflammatory vaccine, stimulates the production of CD4(+)CD25(+) T cells and regulatory cytokines.
13	18684965	In this work, we queried whether Salmonella-CFA/I can protect DBA/1 mice from collagen-induced arthritis.
14	18684965	Clinical findings were accompanied by the suppression of inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-27.
15	18684965	Vaccination evoked a multi-tier response consisting of IL-4 producing Th2 cells, an increased production of TGF-beta by CD4(+) T cells, and suppression of collagen II-specific CD4(+) T cell proliferation.
16	18684965	To assess the contribution of Salmonella-CFA/I-primed CD4(+) T cells, adoptive transfer studies with total CD4(+), CD4(+)CD25(-), or CD4(+)CD25(+) T cells were performed 15 days postchallenge.
17	18684965	Mice receiving either subset showed reduced disease incidence and low clinical scores; however, mice receiving total CD4(+) T cells showed delayed disease onset by 10 days with reduced clinical scores, reduced IL-17 and IL-27, but enhanced IL-4, IL-10, IL-13, and TGF-beta.
18	18684965	Inhibition of TGF-beta or IL-4 compromised protective immunity.
19	18684965	These data show that Salmonella-CFA/I vaccination of DBA/1 mice protects against collagen-induced arthritis by stimulating TGF-beta- and IL-4-producing regulatory CD4(+) T cells.
20	20435931	Knockdown of CD40, CD80, and CD86, prior to loading DCs with the arthritogenic Ag collagen II, led to a population of cells that could effectively suppress onset of collagen-induced arthritis.
21	20435931	Disease suppression was associated with inhibition of collagen II-specific Ab production and suppression of T cell recall responses.
22	20435931	Downregulation of IL-2, IFN-gamma, TNF-alpha, and IL-17 and increased FoxP3(+) cells with regulatory activity were observed in collagen-induced arthritis mice treated with siRNA-transfected DCs.
23	20435931	Knockdown of CD40, CD80, and CD86, prior to loading DCs with the arthritogenic Ag collagen II, led to a population of cells that could effectively suppress onset of collagen-induced arthritis.
24	20435931	Disease suppression was associated with inhibition of collagen II-specific Ab production and suppression of T cell recall responses.
25	20435931	Downregulation of IL-2, IFN-gamma, TNF-alpha, and IL-17 and increased FoxP3(+) cells with regulatory activity were observed in collagen-induced arthritis mice treated with siRNA-transfected DCs.