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Gene Information
Gene symbol: CRMP1
Gene name: collapsin response mediator protein 1
HGNC ID: 2365
Synonyms: DRP-1, DPYSL1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CASP8 | 1 hits |
| 2 | FADD | 1 hits |
| 3 | HABP2 | 1 hits |
| 4 | NLRP3 | 1 hits |
| 5 | RIPK1 | 1 hits |
| 6 | RIPK3 | 1 hits |
| 7 | TICAM1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19012725 | These modified HABPs adopted certain characteristic structural configurations as determined by circular dichroism (CD) and 1H nuclear magnetic resonance (NMR) associated with certain HLA-DRbeta1* haplotype binding activities and characteristics, such as a 2-angstroms-distance difference between amino acids fitting into HLA-DRp1 Pockets 1 to 9, residues participating in binding to HLA-DR pockets and residues making contact with the TCR, suggesting haplotype and allele-conscious TCR. |
| 2 | 26104484 | Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3. |
| 3 | 26104484 | Both pathways require the scaffolding but not the catalytic function of caspase-8 or RIPK1. |
| 4 | 26104484 | Only the late pathway requires kinase competent RIPK3 and MLKL function. |
| 5 | 26104484 | Mechanistically, FADD/caspase-8 scaffolding function provides a post-translational signal 1 in the intermediate pathway, whereas in the late pathway it helps the oligomerization of RIPK3, which together with MLKL provides both signal 1 and 2 for inflammasome assembly. |
| 6 | 26104484 | Cytoplasmic dsRNA activates NLRP3 independent of TRIF, RIPK1, RIPK3 or mitochondrial DRP1, but requires FADD/caspase-8 in wildtype macrophages to remove RIPK3 inhibition. |