Ignet

Gene Information

Gene symbol: CUX1

Gene name: cut-like homeobox 1

HGNC ID: 2557

Synonyms: CDP, CDP1, CUX, CUT, Clox, CDP/Cut, CDP/Cux, Cux/CDP, CASP, GOLIM6

Related Genes

#	Gene Symbol	Number of hits
1	PIK3R2	1 hits
2	PTPN11	1 hits
3	UBASH3B	1 hits

Related Sentences

#	PMID	Sentence
1	18534979	Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity.
2	18534979	Influenza A virus infection activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by binding influenza A virus NS1 protein to the p85beta regulatory subunit of PI3K.
3	18534979	In this study, we report that NS1 binds to the inter-SH2 (iSH2) domain of p85beta.
4	18534979	Mutational analyses on p85beta iSH2 domain defined that Val-573 is the critical amino acid (AA) that mediates NS1 and p85beta interaction.
5	18534979	In reciprocal gain of function experiments with p85alpha, we demonstrated that mutation to Val at Met-582 leads to NS1 binding and increased PI3K activity.
6	18534979	Molecular modeling based on our experimental results suggested that, in addition to the interaction interface between the NS1 SH3 binding motif 1 (AA 164-167) and p85beta Val-573, AA 137-142 in NS1 might interact with p85beta.
7	18534979	Indeed, mutations of AA 141 and 142 in NS1 disrupted the interaction between NS1 and p85beta.
8	18534979	In contrast, in the mutant virus-infected cells containing mutant NS1 unable to interact with p85beta, the p85beta-associated PI3K activity up-regulation was not seen, suggesting that PI3K up-regulation is dependent upon the interaction between NS1 and p85beta.
9	18534979	Competition experiments and the immunoprecipitation studies demonstrated that NS1, p85beta, and p110 form a complex in cells.
10	18534979	Finally, the mechanism by which binding of NS1 to p85beta regulates PI3K activity was discussed based on a predicted structural model of NS1-p85-p110 complex.
11	19523910	The virus was partially attenuated at passage 40 (P40) and P70, and was fully attenuated at P110.
12	19523910	It lost immunogenicity and kidney tropism at P110 and P70, respectively.
13	19523910	Other substitutions that occurred between P70 and P110, however, were found only in some subpopulations of the virus passages.
14	19523910	A 109-bp deletion in the 3'-UTR was observed in most subpopulations of P70 and P110, and might be related to virus replication, transcription and pathogenicity.
15	19523910	The virus was partially attenuated at passage 40 (P40) and P70, and was fully attenuated at P110.
16	19523910	It lost immunogenicity and kidney tropism at P110 and P70, respectively.
17	19523910	Other substitutions that occurred between P70 and P110, however, were found only in some subpopulations of the virus passages.
18	19523910	A 109-bp deletion in the 3'-UTR was observed in most subpopulations of P70 and P110, and might be related to virus replication, transcription and pathogenicity.
19	19523910	The virus was partially attenuated at passage 40 (P40) and P70, and was fully attenuated at P110.
20	19523910	It lost immunogenicity and kidney tropism at P110 and P70, respectively.
21	19523910	Other substitutions that occurred between P70 and P110, however, were found only in some subpopulations of the virus passages.
22	19523910	A 109-bp deletion in the 3'-UTR was observed in most subpopulations of P70 and P110, and might be related to virus replication, transcription and pathogenicity.