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Gene Information
Gene symbol: CX3CL1
Gene name: chemokine (C-X3-C motif) ligand 1
HGNC ID: 10647
Synonyms: NTN, C3Xkine, ABCD-3, CXC3C, CXC3, fractalkine, neurotactin
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AIF1 | 1 hits |
| 2 | CCL1 | 1 hits |
| 3 | CCL2 | 1 hits |
| 4 | CCL5 | 1 hits |
| 5 | CD44 | 1 hits |
| 6 | CD93 | 1 hits |
| 7 | CX3CR1 | 1 hits |
| 8 | IL15 | 1 hits |
| 9 | IL4 | 1 hits |
| 10 | IL5 | 1 hits |
| 11 | IL8 | 1 hits |
| 12 | PTPRC | 1 hits |
| 13 | SELPLG | 1 hits |
| 14 | SPN | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15529257 | RSV G protein contains a CX3C chemokine motif that interacts with the CX3CR1 chemokine receptor and modifies the activities of fractalkine. |
| 2 | 16972041 | Respiratory syncytial virus(RSV)-induced allergy may be controlled by IL-4 and CX3C fractalkine antagonists and CpG ODN as adjuvant: hypothesis and implications for treatment. |
| 3 | 16972041 | Together with CpG ODNs that induce Toll-like receptor 9(+) (TLR9(+)) plasmacytoid dendritic cells to release type I IFN-alpha and -beta will reactivate the inhibited Th1 cells and the antiviral cytotoxic T leukocytes. |
| 4 | 16972040 | It is hypothesized that the viral-soluble G glycoprotein (sG) contains a T cell superantigen (Tsag) that is capable of binding to the V(H)3 domain of IgE/FcepsilonRI(+) hematopoietic cells, basophils, mast cells and monocytes, similar to the case of allergens, and that this aggregation causes these innate system cells to degranulate and release large amounts of Th2 cytokines (IL-4, IL-5, IL-10, IL-13) into the blood. |
| 5 | 16972040 | The review of the molecular research on the role of the viral fusion (F) and attachment (G) glycoproteins of RSV provided information on their role in the virus infection: early in infection the F glycoprotein induces Th1 cells to release the Th1 cytokines IL-2, IL-12 and IFN-gamma to activate precursors CTLs (pCTLs) to become anti-RSV CTLs. |
| 6 | 16972040 | The gradual increase of sG molecules creates a gradient of fractalkine (FKN) which directs IL-5-activated eosinophils to the lungs of the patient. |
| 7 | 21768350 | Substrate specificity was restricted to glycoproteins rich in O-linked glycans, including CD43, CD44, CD45, CD93, CD162 (PSGL-1; P-selectin glycoprotein ligand 1), and the surface-attached chemokine fractalkine, all implicated in leukocyte trafficking, migration, and inflammation. |
| 8 | 22328945 | DEC205-DC targeted DNA vaccines to CX3CR1 and CCL2 are potent and limit macrophage migration. |
| 9 | 22328945 | CX3C chemokine ligand 1 (CX3CL1 & Fractalkine) and its receptor CX3CR1 and monocyte chemoattractant protein 1 (CCL2) have been identified as chemokines/receptors that have an important role in the migration and recruitment of monocytes during the pathogenesis of several inflammatory diseases including atherosclerosis. |
| 10 | 22328945 | DNA vectors containing single chain variable region fragment (scFv) for DC-targeted receptor DEC205 were cloned with mouse CX3CR1 and CCL2 genes respectively, and vaccinated into C57/BL6 mice weekly for 3 weeks. |
| 11 | 24983456 | Here, following grafting of blue fluorescent protein (BFP)-expressing MSC in the CNS of CX3CR1(+/-) and CX3CR1(-/-) mice, our results indicate: (1) that the observed inflammatory response is independent of the fractalkine signalling axis, and (2) that a significant spatial distribution of Iba1(+) inflammatory cells occurs, in which Iba1(+) CX3CR1(+) myeloid cells mainly surround the MSC graft and Iba1(+) CX3CR1(-) myeloid cells mainly invade the graft at 10 days post transplantation. |
| 12 | 24983456 | Although Iba1(+) CX3CR1(+) myeloid cells are considered to be of resident microglial origin, Iba1(+) CX3CR1(-) myeloid cells are most likely of peripheral monocyte/macrophage origin. |
| 13 | 26080445 | We designed a synthetic CX3CL1 variant engineered to have ultra-high affinity for US28 and greater specificity for US28 than the natural sole receptor for CX3CL1, CX3CR1, and we fused the synthetic variant with the cytotoxic domain of Pseudomonas Exotoxin A. |
| 14 | 26297201 | The G protein also has a CX3C chemokine motif which binds to the fractalkine receptor CX3CR1. |
| 15 | 26297201 | The kinetics of cytokine production suggested that the RSV/CX3CR1 interaction induced RANTES (regulated on activation normal T-cell expressed and secreted protein), IL-8 and fractalkine production, whilst it downregulated IL-15, IL1-RA and monocyte chemotactic protein-1. |
| 16 | 26297201 | The G protein also has a CX3C chemokine motif which binds to the fractalkine receptor CX3CR1. |
| 17 | 26297201 | The kinetics of cytokine production suggested that the RSV/CX3CR1 interaction induced RANTES (regulated on activation normal T-cell expressed and secreted protein), IL-8 and fractalkine production, whilst it downregulated IL-15, IL1-RA and monocyte chemotactic protein-1. |
| 18 | 26473935 | In this study, we show that vaccination with layer-by-layer nanoparticles (LbL-NP) carrying the G protein CX3C motif induces blocking antibodies that prevent the interaction of the RSV G protein with the fractalkine receptor (CX3CR1) and protect mice against RSV replication and disease pathogenesis. |