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Gene Information
Gene symbol: CXCL1
Gene name: chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
HGNC ID: 4602
Synonyms: SCYB1, GROa, MGSA-a, NAP-3
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | C5AR1 | 1 hits |
| 2 | CAMP | 1 hits |
| 3 | CCL2 | 1 hits |
| 4 | CCL3 | 1 hits |
| 5 | CCL5 | 1 hits |
| 6 | CSF3 | 1 hits |
| 7 | CXCL10 | 1 hits |
| 8 | CXCL2 | 1 hits |
| 9 | CXCL3 | 1 hits |
| 10 | IL18 | 1 hits |
| 11 | IL1B | 1 hits |
| 12 | IL6 | 1 hits |
| 13 | IL8 | 1 hits |
| 14 | LTA | 1 hits |
| 15 | LTB | 1 hits |
| 16 | TLR4 | 1 hits |
| 17 | TLR7 | 1 hits |
| 18 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17073942 | Thirty-one immunologically characterized genes were differentially expressed by DCs following exposure to Live-EB or UV-EB, including two glutamic acid-leucine-arginine cysteine-X-cysteine (ELR CXC) neutrophil chemoattractant chemokines, Cxcl1 (KC), and Cxcl2 (MIP-2). |
| 2 | 20826612 | The concentrations of several chemoattractants for neutrophils (CXCL1, CXCL2, CXCL3, CXCL8, and C5a) increased in milk after challenge, and the highest increases followed challenge with the combination of MDP and LTA. |
| 3 | 20826612 | Nucleotide-binding oligomerization domain 2 (NOD2), a major sensor of MDP, was expressed (mRNA) in bovine mammary tissue and by bMEpC in culture. |
| 4 | 20826612 | The production of interleukin-8 (IL-8) following the stimulation of bMEpC by LTA and MDP was dependent on the activation of NF-κB. |
| 5 | 20826612 | LTA-induced IL-8 production did not depend on platelet-activating factor receptor (PAFR), as the PAFR antagonist WEB2086 was without effect. |
| 6 | 20826612 | Although the levels of expression of the inflammatory cytokines tumor necrosis factor alpha (TNF-α) and IL-1β were increased by LTA and MDP at the mRNA level, no protein could be detected in the bMEpC culture supernatant. |
| 7 | 20826612 | Overall, this study indicates that the TLR2 and NOD2 pathways could cooperate to trigger an innate immune response to S. aureus mastitis. |
| 8 | 21072873 | TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin. |
| 9 | 21072873 | Thus, we examined the ability of flagellin to induce cytokines and elicit/promote murine antibody responses upon deletion of the flagellin receptors TLR5 and/or NLRC4 (also referred to as IPAF) using a prime/boost regimen. |
| 10 | 21072873 | In TLR5-KO mice, flagellin failed to induce NF-κB-regulated cytokines such as keratinocyte-derived chemokine (CXCL1) but induced WT levels of the inflammasome cytokine IL-18 (IL-1F4). |
| 11 | 21169550 | Priming with live lactobacilli resulted in diminished granulocyte recruitment, diminished expression of multiple proinflammatory cytokines (CXCL10, CXCL1, CCL2, and TNF), and reduced virus recovery, although we have demonstrated clearly that absolute virus titer does not predict clinical outcome. |
| 12 | 21256188 | The presence of α-tocopherol also modulated the expression of some cytokines, including CCL2, CCL3, IL-6, CSF3 and CXCL1; increased the antigen loading in monocytes; and increased the recruitment of granulocytes in the dLNs. |
| 13 | 21839740 | Gene expression for T-helper-1 (Th1) polarizing cytokines (TNF-α, IL-1β, IL-12) and chemokines (CXCL1, CCL2) was upregulated following ex vivo stimulation of guinea pig splenocytes and whole blood with TLR-4 or TLR-7/8 agonists. |
| 14 | 22009111 | The appropriate size of the LTB(4)/CFAgs-loaded MS (smaller than 10μm) enabled the efficient uptake by BMDM and also induced TNF-α, CXCL1/KC, CCL2/MCP-1, CCL5/RANTES and nitrite oxide release by these cells. |
| 15 | 23500517 | Increased levels of pro-inflammatory cytokine IL-6, chemokines monocyte chemoattractant protein 1 (MCP-1) and CXCL1 with increased neutrophil influx into the lungs were observed in uninfected mice after intranasal administration of LL-37. |
| 16 | 23500517 | Following LVS challenge, LL-37 administration resulted in increased IL-6, IL-12 p70, IFNγ and MCP-1 production, a slowing of LVS growth in the lung, and a significant extension of mean time to death compared to control mice. |
| 17 | 23603355 | An increased release of CCL2/MCP-1 and CXCL1/KC was also observed, resulting in macrophage and neutrophil recruitment in vitro. |
| 18 | 23603355 | Lastly, the incubation of macrophages with KMP-11-loaded PLGA nanoparticles triggered the activation of caspase-1 and the secretion of IL-1β and IL-18, suggesting inflammasome participation. |