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Gene Information
Gene symbol: DEFA1
Gene name: defensin, alpha 1
HGNC ID: 2761
Synonyms: HNP-1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ART1 | 1 hits |
| 2 | ART3 | 1 hits |
| 3 | CD4 | 1 hits |
| 4 | DEFA3 | 1 hits |
| 5 | DEFB1 | 1 hits |
| 6 | IFNG | 1 hits |
| 7 | XCL1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10741861 | Serum antigen-specific antibody (Ab) responses were enhanced when either IL-6 or IL-12 was mucosally administered with a protein antigen, while only IL-12 induced antigen-specific mucosal IgA Ab responses. |
| 2 | 10741861 | Mucosal IL-6 and IL-12 also affected the type of Th cell responses induced by CD4+ T cells from mice that received IL-12 secreted larger amounts of IFN-gamma and IL-6 when compared with mice nasally treated with IL-6. |
| 3 | 10741861 | Mixed antigen-specific Th1 -and Th2-type CD4+ T cell responses were induced in the systemic compartment by both lymphotactin and the mixture of HNP-1, HNP-2, and HNP-3 defensins. |
| 4 | 10741861 | In summary, these studies clearly show that IL-12 and lymphotactin are able to trigger S-IgA Ab responses and provide new avenues for the design of safe and targeted mucosal vaccines. |
| 5 | 17655941 | Neither induction of IFN-stimulated genes (ISGs) by HNP1 nor their antiviral activity against fish rhabovirus has been previously reported. |
| 6 | 22879887 | Cholera toxin (CT) from Vibrio cholerae and heat labile enterotoxin (LT) from Escherichia coli both modified the human α-defensin (HNP-1) and β- defensin-1 (HBD1), as efficiently as the mammalian mono-ADP-ribosyltransferase-1. |
| 7 | 22879887 | Pseudomonas aeruginosa exoenzyme S was inactive on both HNP-1 and HBD1. |
| 8 | 22879887 | Neisseria meningitidis NarE poorly recognized HNP-1 as a substrate but it was completely inactive on HBD1. |
| 9 | 22879887 | Cholera toxin (CT) from Vibrio cholerae and heat labile enterotoxin (LT) from Escherichia coli both modified the human α-defensin (HNP-1) and β- defensin-1 (HBD1), as efficiently as the mammalian mono-ADP-ribosyltransferase-1. |
| 10 | 22879887 | Pseudomonas aeruginosa exoenzyme S was inactive on both HNP-1 and HBD1. |
| 11 | 22879887 | Neisseria meningitidis NarE poorly recognized HNP-1 as a substrate but it was completely inactive on HBD1. |
| 12 | 22879887 | Cholera toxin (CT) from Vibrio cholerae and heat labile enterotoxin (LT) from Escherichia coli both modified the human α-defensin (HNP-1) and β- defensin-1 (HBD1), as efficiently as the mammalian mono-ADP-ribosyltransferase-1. |
| 13 | 22879887 | Pseudomonas aeruginosa exoenzyme S was inactive on both HNP-1 and HBD1. |
| 14 | 22879887 | Neisseria meningitidis NarE poorly recognized HNP-1 as a substrate but it was completely inactive on HBD1. |