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Gene Information
Gene symbol: DHPS
Gene name: deoxyhypusine synthase
HGNC ID: 2869
Synonyms: MIG13
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | DHFR | 1 hits |
| 2 | EIF5 | 1 hits |
| 3 | EIF5A | 1 hits |
| 4 | GFER | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12490407 | In turn, the eukaryotic initiation factor (eIF-5A) is indispensable for Rev function and is the only known protein whose biologically active form requires the unique amino acid, hypusine. |
| 2 | 12490407 | Because 1,8-diaminooctane blocks the formation of hypusine by disrupting the cellular enzyme, deoxyhypusine synthase, thereby preventing activation of eIF-5A, we investigated the effects of 1,8-diaminooctane on posttranscriptional regulation. |
| 3 | 12490407 | The findings of this study are the first demonstration that FIV, similar to HIV-1, requires eIF-5A for efficient Rev function and that small molecule intervention can indirectly target this lentivirus regulatory system. |
| 4 | 14530966 | Here, we present data that pinpoint the existence of two enzymes of the polyamine pathway involved in spermidine metabolism in P. falciparum, i.e. deoxyhypusine synthase (DHS; EC 1.1.1.249) and homospermidine synthase (HSS; EC 2.5.1.45). |
| 5 | 17092820 | The role of DHFR and DHPS mutations in therapeutic failure of antifolate antimalarials is less clear. |