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Gene Information
Gene symbol: DIRAS1
Gene name: DIRAS family, GTP-binding RAS-like 1
HGNC ID: 19127
Synonyms: Di-Ras1, GBTS1, RIG
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATN1 | 1 hits |
| 2 | DDX58 | 1 hits |
| 3 | IFNG | 1 hits |
| 4 | PTPN22 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17370119 | In particular, newly identified intracellular retinoic-acid-inducible gene (RIG)-like receptors, NOD-like receptors, or even as yet unknown recognition machinery for the adjuvant may regulate TLR-independent vaccine immunogenicity. |
| 2 | 18516301 | Compared to rhMPV-WT, rhMPV-Delta G also increased IRF- and NF-kappaB-dependent gene transcription, which was reversely inhibited by G protein expression. |
| 3 | 18516301 | Since RNA helicases have been shown to play a fundamental role in initiating viral-induced cellular signaling, we investigated whether retinoic induced gene (RIG)-I was the target of G protein inhibitory activity. |
| 4 | 23626834 | Recent investigations in our lab identified hMPV glycoprotein G as an important virulence factor, as a recombinant virus lacking the G protein (rhMPV-ΔG) exhibited enhanced production of important immune and antiviral mediators, such as cytokines, chemokines and type I interferon (IFN) in airway epithelial cells, and expression of G protein alone inhibits cellular signaling dependent on retinoic induced gene (RIG)-I, a RNA helicase with a fundamental role in initiating hMPV-induced cellular responses. |
| 5 | 23626834 | We found that the interaction of hMPV G with RIG-I occurs primarily through the CARD domains of RIG-I N-terminus, preventing RIG-I association with the adaptor protein MAVS (mitochondrial antiviral signaling protein), recruitment of RIG-I to mitochondria, as well as the interaction between mitochondria and mitochondria-associated membrane (MAM) component of the endoplasmic reticulum (ER), which contains STINGS, an important part of the viral-induced RIG-I/MAVS signaling pathway, leading in the end to the inhibition of cytokine, chemokine and type I IFN expression. |
| 6 | 26325475 | The well-known Fos and Jun leucine zippers were utilized to dimerize VH and VL similarly to the IgG counterpart. |
| 7 | 26325475 | Our results not only indicated zipFv57S as an ideal alternative for RIG in PEP but also offered a novel and efficient hetero-dimerization pattern of VH and VL leading to enhanced neutralizing potency. |