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Gene Information
Gene symbol: E2F1
Gene name: E2F transcription factor 1
HGNC ID: 3113
Synonyms: RBP3
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BRCA1 | 1 hits |
| 2 | CASP8 | 1 hits |
| 3 | CDKN1A | 1 hits |
| 4 | CDKN2A | 1 hits |
| 5 | CHEK1 | 1 hits |
| 6 | FAS | 1 hits |
| 7 | MDM2 | 1 hits |
| 8 | RAD51 | 1 hits |
| 9 | TP53 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15240700 | The E2F-1 transcription factor promotes caspase-8 and bid expression, and enhances Fas signaling in T cells. |
| 2 | 23687157 | The CEL-im cell line has negative telomerase activity, and when compared with the primary passage 2 CEL cell counterpart, mRNA expression of tumor suppressor protein p53, mouse double minute 2 (Mdm2), cyclin dependent kinase (CDK) inhibitor p21 (p21(WAF)), and CDK inhibitor p16 (p16(INK4)) were downregulated in the CEL-im cell line, whereas retinoblastoma (Rb), transcription factor E2F, member 1 (E2F-1), and alternative reading frame of p16(INK4) (ARF) were upregulated. |
| 3 | 24244429 | Panobinostat enhances cytarabine and daunorubicin sensitivities in AML cells through suppressing the expression of BRCA1, CHK1, and Rad51. |
| 4 | 24244429 | Panobinostat suppressed expression of BRCA1, CHK1, and RAD51 in AML cells in a dose-dependent manner. |
| 5 | 24244429 | Analogous results were obtained by shRNA knockdown of BRCA1, CHK1, or RAD51. |
| 6 | 24244429 | Additional studies revealed that panobinostat suppressed the expression of BRCA1, CHK1, and RAD51 through downregulation of E2F1 transcription factor. |
| 7 | 24244429 | Our results establish a novel mechanism underlying the cooperative antileukemic activities of these drug combinations in which panobinostat suppresses expression of BRCA1, CHK1, and RAD51 to enhance cytarabine and daunorubicin sensitivities in AML cells. |