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Gene Information
Gene symbol: EBI2
Gene name: Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)
HGNC ID: 3128
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BCL6 | 1 hits |
| 2 | CCR7 | 1 hits |
| 3 | CD4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 22427637 | Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation. |
| 2 | 22427637 | The introduction of Bcl6 expression in primary human CD4 T cells resulted in the regulation of a core set of migration genes that enable trafficking to germinal centers: CXCR4, CXCR5, CCR7, and EBI2. |
| 3 | 22427637 | Bcl6 expression also induced a module of protein expression critical for T-B interactions, including SAP, CD40L, PD-1, ICOS, and CXCL13. |
| 4 | 22427637 | This constitutes direct evidence for Bcl6 control of most of these functions and includes three genes known to be loci of severe human genetic immunodeficiencies (CD40L, SH2D1A, and ICOS). |
| 5 | 22427637 | Introduction of Bcl6 did not alter the expression of IL-21 or IL-4, the primary cytokines of human Tfh cells. |
| 6 | 22427637 | Coexpression of Bcl6 and Maf revealed that Bcl6 and Maf cooperate in the induction of CXCR4, PD-1, and ICOS. |
| 7 | 22427637 | Altogether, these findings reveal that Bcl6 and Maf collaborate to orchestrate a suite of genes that define core characteristics of human Tfh cell biology. |