Ignet

Gene Information

Gene symbol: EBI3

Gene name: Epstein-Barr virus induced 3

HGNC ID: 3129

Related Genes

#	Gene Symbol	Number of hits
1	C19orf10	1 hits
2	CD4	1 hits
3	CD8A	1 hits
4	FOXP3	1 hits
5	IL10	1 hits
6	IL12A	1 hits
7	IL17D	1 hits
8	IL23A	1 hits
9	IL27	1 hits
10	IL9	1 hits

Related Sentences

#	PMID	Sentence
1	16369012	Plasmid interleukin-23 (IL-23), but not plasmid IL-27, enhances the protective efficacy of a DNA vaccine against Mycobacterium tuberculosis infection.
2	16369012	Three heterodimeric cytokines, interleukin-12 (IL-12), IL-23, and IL-27, as well as IL-18, contribute to the differentiation and expansion of naive CD4(+) T cells.
3	16369012	In this study we compared the effects of plasmids expressing both chains of IL-12, IL-23, or IL-27 as adjuvants for DNA immunization against M. tuberculosis infection.
4	16369012	The genes encoding p19 and p40 chains of IL-23 or EBI3 and p28 chains of IL-27 were cloned on either side of a self-cleaving peptide from the FMDV2A protein.
5	16369012	Supernatant from p2AIL-23-transfected cells induced the release of IL-17 from activated lymphocytes, confirming the presence of bioactive IL-23.
6	16369012	In initial experiments, M. tuberculosis infection of DCs was more potent at inducing IL-12 and IL-23 secretion than infection with the vaccine strain Mycobacterium bovis bacille Calmette-Guérin (BCG), and no significant upregulation of IL-27 was observed.
7	16369012	Coimmunization of C57BL/6 mice with DNA expressing M. tuberculosis antigen 85B (Ag85B; DNA85B) and plasmids expressing IL-23 or IL-12 stimulated stronger Ag85B-specific T-cell proliferative and IFN-gamma responses than DNA85B alone, whereas the addition of p2AIL-27 had no effect.
8	18033300	Here we demonstrate that Epstein-Barr-virus-induced gene 3 (Ebi3, which encodes IL-27beta) and interleukin-12 alpha (Il12a, which encodes IL-12alpha/p35) are highly expressed by mouse Foxp3+ (forkhead box P3) T(reg) cells but not by resting or activated effector CD4+ T (T(eff)) cells, and that an Ebi3-IL-12alpha heterodimer is constitutively secreted by T(reg) but not T(eff) cells.
9	18033300	Both Ebi3 and Il12a messenger RNA are markedly upregulated in T(reg) cells co-cultured with T(eff) cells, thereby boosting Ebi3 and IL-12alpha production in trans.
10	18033300	T(reg)-cell restriction of this cytokine occurs because Ebi3 is a downstream target of Foxp3, a transcription factor that is required for T(reg)-cell development and function.
11	18033300	Here we demonstrate that Epstein-Barr-virus-induced gene 3 (Ebi3, which encodes IL-27beta) and interleukin-12 alpha (Il12a, which encodes IL-12alpha/p35) are highly expressed by mouse Foxp3+ (forkhead box P3) T(reg) cells but not by resting or activated effector CD4+ T (T(eff)) cells, and that an Ebi3-IL-12alpha heterodimer is constitutively secreted by T(reg) but not T(eff) cells.
12	18033300	Both Ebi3 and Il12a messenger RNA are markedly upregulated in T(reg) cells co-cultured with T(eff) cells, thereby boosting Ebi3 and IL-12alpha production in trans.
13	18033300	T(reg)-cell restriction of this cytokine occurs because Ebi3 is a downstream target of Foxp3, a transcription factor that is required for T(reg)-cell development and function.
14	18033300	Here we demonstrate that Epstein-Barr-virus-induced gene 3 (Ebi3, which encodes IL-27beta) and interleukin-12 alpha (Il12a, which encodes IL-12alpha/p35) are highly expressed by mouse Foxp3+ (forkhead box P3) T(reg) cells but not by resting or activated effector CD4+ T (T(eff)) cells, and that an Ebi3-IL-12alpha heterodimer is constitutively secreted by T(reg) but not T(eff) cells.
15	18033300	Both Ebi3 and Il12a messenger RNA are markedly upregulated in T(reg) cells co-cultured with T(eff) cells, thereby boosting Ebi3 and IL-12alpha production in trans.
16	18033300	T(reg)-cell restriction of this cytokine occurs because Ebi3 is a downstream target of Foxp3, a transcription factor that is required for T(reg)-cell development and function.
17	19275692	IL-27 and IL-23 are two cytokines that are related to IL-12; these cytokines share homology at the subunit, receptor, and signalling levels.
18	19275692	IL-12 is composed of p35 and p40 subunits, which, when combined together form the bioactive IL-12p70.
19	19275692	IL-27 is composed of EBI3 and p28.
20	19275692	IL-12 is required for the induction of IFN-gamma production, critical for the induction of Th1 cells.
21	19275692	IL-27 has been shown to play a role in the induction of Th1 cells from naive T cells, whereas IL-23 has been demonstrated to play a key role in the induction of the newly described Th17 cells.
22	23472662	It contains Epstein-Barr virus-induced gene 3 subunit and IL-27 p35 subunit.
23	23472662	Although its receptor and signaling pathway are not clear, we presumed that its receptor is composed by two chains that might be similar to those receptors of IL-12, IL-23, and IL-27.
24	26140252	Epstein-Barr virus-induced gene 3 (EBI3) encoded protein can form heterodimers with IL-27P28, and IL-12P35 to form IL-27, and IL-35.
25	26140252	In this study, we evaluated the tumor growth and antitumor T-cell responses in EBI3-deficient mice that lack both IL-27 and IL-35.
26	26140252	Tumors from EBI3-deficient mice contained significantly decreased proportions of CD8⁺ T cells and increased proportions of CD4⁺FoxP3⁺ Treg cells as compared to those from EBI3-intact mice.
27	26140252	Phenotypically, Tregs from EBI3-deficient mice were highly suppressive and produced IL-10 in the tumor microenvironment.
28	26140252	Depletion of Tregs or inactivation of the IL-10 pathway significantly abrogated tumor growth enhancement in Ebi3^-/- mice.
29	26140252	Finally, we showed that Ebi3^-/- mice administered a melanoma vaccine failed to mount a CD8⁺ T-cell response and the vaccine failed to confer tumor rejection in EBI3-deficient mice.
30	26140252	Taken together, these results suggest that Ebi3^-/- mice show a phenotype of IL-27-deficiency rather than IL-35-deficiency during anti-tumor T-cell responses.
31	26140252	Epstein-Barr virus-induced gene 3 (EBI3) encoded protein can form heterodimers with IL-27P28, and IL-12P35 to form IL-27, and IL-35.
32	26140252	In this study, we evaluated the tumor growth and antitumor T-cell responses in EBI3-deficient mice that lack both IL-27 and IL-35.
33	26140252	Tumors from EBI3-deficient mice contained significantly decreased proportions of CD8⁺ T cells and increased proportions of CD4⁺FoxP3⁺ Treg cells as compared to those from EBI3-intact mice.
34	26140252	Phenotypically, Tregs from EBI3-deficient mice were highly suppressive and produced IL-10 in the tumor microenvironment.
35	26140252	Depletion of Tregs or inactivation of the IL-10 pathway significantly abrogated tumor growth enhancement in Ebi3^-/- mice.
36	26140252	Finally, we showed that Ebi3^-/- mice administered a melanoma vaccine failed to mount a CD8⁺ T-cell response and the vaccine failed to confer tumor rejection in EBI3-deficient mice.
37	26140252	Taken together, these results suggest that Ebi3^-/- mice show a phenotype of IL-27-deficiency rather than IL-35-deficiency during anti-tumor T-cell responses.
38	26140252	Epstein-Barr virus-induced gene 3 (EBI3) encoded protein can form heterodimers with IL-27P28, and IL-12P35 to form IL-27, and IL-35.
39	26140252	In this study, we evaluated the tumor growth and antitumor T-cell responses in EBI3-deficient mice that lack both IL-27 and IL-35.
40	26140252	Tumors from EBI3-deficient mice contained significantly decreased proportions of CD8⁺ T cells and increased proportions of CD4⁺FoxP3⁺ Treg cells as compared to those from EBI3-intact mice.
41	26140252	Phenotypically, Tregs from EBI3-deficient mice were highly suppressive and produced IL-10 in the tumor microenvironment.
42	26140252	Depletion of Tregs or inactivation of the IL-10 pathway significantly abrogated tumor growth enhancement in Ebi3^-/- mice.
43	26140252	Finally, we showed that Ebi3^-/- mice administered a melanoma vaccine failed to mount a CD8⁺ T-cell response and the vaccine failed to confer tumor rejection in EBI3-deficient mice.
44	26140252	Taken together, these results suggest that Ebi3^-/- mice show a phenotype of IL-27-deficiency rather than IL-35-deficiency during anti-tumor T-cell responses.
45	26140252	Epstein-Barr virus-induced gene 3 (EBI3) encoded protein can form heterodimers with IL-27P28, and IL-12P35 to form IL-27, and IL-35.
46	26140252	In this study, we evaluated the tumor growth and antitumor T-cell responses in EBI3-deficient mice that lack both IL-27 and IL-35.
47	26140252	Tumors from EBI3-deficient mice contained significantly decreased proportions of CD8⁺ T cells and increased proportions of CD4⁺FoxP3⁺ Treg cells as compared to those from EBI3-intact mice.
48	26140252	Phenotypically, Tregs from EBI3-deficient mice were highly suppressive and produced IL-10 in the tumor microenvironment.
49	26140252	Depletion of Tregs or inactivation of the IL-10 pathway significantly abrogated tumor growth enhancement in Ebi3^-/- mice.
50	26140252	Finally, we showed that Ebi3^-/- mice administered a melanoma vaccine failed to mount a CD8⁺ T-cell response and the vaccine failed to confer tumor rejection in EBI3-deficient mice.
51	26140252	Taken together, these results suggest that Ebi3^-/- mice show a phenotype of IL-27-deficiency rather than IL-35-deficiency during anti-tumor T-cell responses.
52	26140252	Epstein-Barr virus-induced gene 3 (EBI3) encoded protein can form heterodimers with IL-27P28, and IL-12P35 to form IL-27, and IL-35.
53	26140252	In this study, we evaluated the tumor growth and antitumor T-cell responses in EBI3-deficient mice that lack both IL-27 and IL-35.
54	26140252	Tumors from EBI3-deficient mice contained significantly decreased proportions of CD8⁺ T cells and increased proportions of CD4⁺FoxP3⁺ Treg cells as compared to those from EBI3-intact mice.
55	26140252	Phenotypically, Tregs from EBI3-deficient mice were highly suppressive and produced IL-10 in the tumor microenvironment.
56	26140252	Depletion of Tregs or inactivation of the IL-10 pathway significantly abrogated tumor growth enhancement in Ebi3^-/- mice.
57	26140252	Finally, we showed that Ebi3^-/- mice administered a melanoma vaccine failed to mount a CD8⁺ T-cell response and the vaccine failed to confer tumor rejection in EBI3-deficient mice.
58	26140252	Taken together, these results suggest that Ebi3^-/- mice show a phenotype of IL-27-deficiency rather than IL-35-deficiency during anti-tumor T-cell responses.
59	26140252	Epstein-Barr virus-induced gene 3 (EBI3) encoded protein can form heterodimers with IL-27P28, and IL-12P35 to form IL-27, and IL-35.
60	26140252	In this study, we evaluated the tumor growth and antitumor T-cell responses in EBI3-deficient mice that lack both IL-27 and IL-35.
61	26140252	Tumors from EBI3-deficient mice contained significantly decreased proportions of CD8⁺ T cells and increased proportions of CD4⁺FoxP3⁺ Treg cells as compared to those from EBI3-intact mice.
62	26140252	Phenotypically, Tregs from EBI3-deficient mice were highly suppressive and produced IL-10 in the tumor microenvironment.
63	26140252	Depletion of Tregs or inactivation of the IL-10 pathway significantly abrogated tumor growth enhancement in Ebi3^-/- mice.
64	26140252	Finally, we showed that Ebi3^-/- mice administered a melanoma vaccine failed to mount a CD8⁺ T-cell response and the vaccine failed to confer tumor rejection in EBI3-deficient mice.
65	26140252	Taken together, these results suggest that Ebi3^-/- mice show a phenotype of IL-27-deficiency rather than IL-35-deficiency during anti-tumor T-cell responses.
66	26140252	Epstein-Barr virus-induced gene 3 (EBI3) encoded protein can form heterodimers with IL-27P28, and IL-12P35 to form IL-27, and IL-35.
67	26140252	In this study, we evaluated the tumor growth and antitumor T-cell responses in EBI3-deficient mice that lack both IL-27 and IL-35.
68	26140252	Tumors from EBI3-deficient mice contained significantly decreased proportions of CD8⁺ T cells and increased proportions of CD4⁺FoxP3⁺ Treg cells as compared to those from EBI3-intact mice.
69	26140252	Phenotypically, Tregs from EBI3-deficient mice were highly suppressive and produced IL-10 in the tumor microenvironment.
70	26140252	Depletion of Tregs or inactivation of the IL-10 pathway significantly abrogated tumor growth enhancement in Ebi3^-/- mice.
71	26140252	Finally, we showed that Ebi3^-/- mice administered a melanoma vaccine failed to mount a CD8⁺ T-cell response and the vaccine failed to confer tumor rejection in EBI3-deficient mice.
72	26140252	Taken together, these results suggest that Ebi3^-/- mice show a phenotype of IL-27-deficiency rather than IL-35-deficiency during anti-tumor T-cell responses.
73	26236666	Increased P-35, EBI3 Transcripts and Other Treg Markers in Peripheral Blood Mononuclear Cells of Breast Cancer Patients with Different clinical Stages.