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Gene Information
Gene symbol: EEA1
Gene name: early endosome antigen 1
HGNC ID: 3185
Synonyms: ZFYVE2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | CTSD | 1 hits |
| 3 | HLA-A | 1 hits |
| 4 | LAMP1 | 1 hits |
| 5 | LAMP2 | 1 hits |
| 6 | LY75 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15036539 | Both RB51 strains were transiently observed in phagosomes characterized by the presence of the early endosomal marker EEA1 and then were found in cathepsin D-enriched lysosomal compartments, in which they eventually underwent degradation at later post-infection times. |
| 2 | 18593941 | Applying cryosurgery as an instant in situ tumor destruction technique, we now show that timing of CpG administration crucially affects colocalization of antigen and CpG within EEA-1(+) and LAMP-1(+) compartments within dendritic cells in vivo. |
| 3 | 20421949 | VACV was not delivered to the classical endolysosomal pathway, failing to colocalise with EEA1 or Lamp2. |
| 4 | 23729440 | Consistent with their specific receptor expression, skin DCs bound and internalized Env via C-type lectin receptors, whereas blood DC subsets, including CD1c(+) myeloid DCs, CD123(+) plasmacytoid DCs (PDCs), and CD141(+) DCs exhibited a restricted repertoire of C-type lectin receptors and relied on CD4 for uptake of Env. |
| 5 | 23729440 | Despite a generally poor capacity for Ag uptake compared with myeloid DCs, the high expression of CD4 on PDCs allowed them to bind and internalize Env very efficiently. |
| 6 | 23729440 | CD4-mediated uptake delivered Env to EEA1(+) endosomes that progressed to Lamp1(+) and MHC class II(+) lysosomes where internalized Env was degraded rapidly. |
| 7 | 25419128 | Targeting human dendritic cells via DEC-205 using PLGA nanoparticles leads to enhanced cross-presentation of a melanoma-associated antigen. |
| 8 | 25419128 | In addition, the DEC-205-labeled nanoparticles rapidly escape from the DC endosomal compartment and do not colocalize with markers of early (EEA-1) or late endosome/lysosome (LAMP-1). |