Ignet

Gene Information

Gene symbol: EIF2S1

Gene name: eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

HGNC ID: 3265

Synonyms: EIF-2alpha, EIF2A

Related Genes

#	Gene Symbol	Number of hits
1	AKT1	1 hits
2	ANXA1	1 hits
3	ATF4	1 hits
4	ATF6	1 hits
5	CALR	1 hits
6	CASP3	1 hits
7	CYCS	1 hits
8	DDIT3	1 hits
9	EIF2A	1 hits
10	EIF2AK2	1 hits
11	EIF2AK3	1 hits
12	EIF2B1	1 hits
13	HSPA5	1 hits
14	IRF3	1 hits
15	MAPK8	1 hits
16	MAPK9	1 hits
17	PGAM2	1 hits
18	PIK3CA	1 hits
19	SOD1	1 hits

Related Sentences

#	PMID	Sentence
1	2845653	The ICF activity appeared to copurify with a complex of initiation factors eIF-2 and eIF-2B.
2	16731942	During the course of infection in HeLa cells, there is a translational block induced by NYVAC late in infection, which correlated with a marked increase in phosphorylation levels of the initiation factor eIF-2alpha.
3	22001879	NYCBHΔE3L induced phosphorylation of PKR and eIF2α as well as p38, SAPK/JNK, and IRF3 which can lead to induction of proinflammatory gene transcription.
4	23251389	Wogonin induced calreticulin/annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner.
5	23251389	Here we demonstrated for the first time that wogonin elicits a potent antitumor immunity effect by inducing the translocation of calreticulin (CRT) and Annexin A1 to cell plasma membrane as well as the release of high-mobility group protein 1 (HMGB1) and ATP.
6	23251389	We found that wogonin-induced reactive oxygen species (ROS) production causes an endoplasmic reticulum (ER) stress response, including the phosphorylation of PERK (PKR-like endoplasmic reticulum kinase)/PKR (protein kinase R) and eIF2α (eukaryotic initiation factor 2α), which served as upstream signal for the activation of phosphoinositide 3-kinase (PI3K)/AKT, inducing calreticulin (CRT)/Annexin A1 cell membrane translocation.
7	23251389	P22/CHP, a Ca(2+)-binding protein, was associated with CRT and was required for CRT translocation to cell membrane.
8	23251389	In conclusion, the activation of PI3K pathway elicited by ER stress induced CRT/Annexin A1 translocation ("eat me" signal) and HMGB1 release, mediating wogonin-induced immunity of tumor cell vaccine.
9	23487469	ICP34.5β is unable to counteract PKR-mediated eIF2 phosphorylation but does not interfere with ICP34.5α's function in this process.
10	24297695	In these upregulated genes in 23DSI, phosphoglycerate mutase, superoxide dismutase, egg antigen, ribosomal proteins, ferritin-1 heavy chain, and eukaryotic translation initiation factor 2 were detected.
11	25633898	Finally, we discovered the over-expression of GRP78, ATF4, ATF6, PERK, eIF2α, CHOP, and cytochrome c (Cyt-c) but not IRE1, xbp-1, and caspase-3 in B.suis.S2 (HK)-attacked and B.suis.S2-infected cells, suggesting that the molecular mechanism of ER stress sensor activation by B.suis.S2 is basically concomitant with that by B.suis.S2 (HK) and that ER stress, especially the PERK pathway, plays an important role in the process of B.suis.S2 infecting EEC, which may, in part, explain the role of the uterus in the pathogenesis of B.suis.S2.