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Gene Information
Gene symbol: EML4
Gene name: echinoderm microtubule associated protein like 4
HGNC ID: 1316
Synonyms: ROPP120, ELP120
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ALK | 1 hits |
| 2 | EGFR | 1 hits |
| 3 | EML1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 22443647 | The monoclonal antibody to EGFR, cetuximab, improves survival in patients with metastatic NSCLC, and the inhibitor of the echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion protein, crizotinib, has resulted in an unprecedented overall survival advantage in patients harboring the EML4-ALK translocation. |
| 2 | 22443647 | In the adjuvant setting, gefitinib has not been shown to improve patient survival outcomes; however, there are several ongoing clinical trials in the adjuvant setting evaluating the role of erlotinib, bevacizumab, and the MAGE-A3 and MUC1 vaccines. |
| 3 | 22443647 | Several ongoing clinical trials in both the metastatic and adjuvant settings are studying the excision repair cross-complementing group 1 (ERCC1) protein, the ribonucleotide reductase subunit 1 (RRM1) protein, thymidylate synthase, and BRCA1 as predictors of chemotherapy response. |