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Gene Information
Gene symbol: ERAP1
Gene name: endoplasmic reticulum aminopeptidase 1
HGNC ID: 18173
Synonyms: ARTS-1, A-LAP, PILS-AP, KIAA0525, ERAAP1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD8A | 1 hits |
| 2 | FLNB | 1 hits |
| 3 | LAP3 | 1 hits |
| 4 | NR1I3 | 1 hits |
| 5 | NRSN1 | 1 hits |
| 6 | POLE3 | 1 hits |
| 7 | RING1 | 1 hits |
| 8 | SRC | 1 hits |
| 9 | ST20 | 1 hits |
| 10 | WWOX | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18262499 | Among various synthetic substrates tested, the purified enzyme hydrolysed Leu-p-NA at very high rate suggesting it to be a LAP. |
| 2 | 19075917 | Some of the patents and patent applications discuss newly discovered tumor suppressor genes, including WW Domain-Containing Oxidoreductase (WWOX), Cancer Associated Ring-1 (CAR-1), Human Cervical Cancer Suppressor 1 (HCCS-1), Src-suppressed C kinase substrate (SSeCKS), ADP-Ribosylation factor-like putative Tumor Suppressor gene 1 (ARTS1), and Deleted in Osteosarcoma (DOS). |
| 3 | 19075917 | Another patent application recently published describes a chimeric tumor suppressor gene generated by combining a portion of the rat PEG-3 protein with the human GADD34 protein, thus creating a protein with apoptotic activity. |
| 4 | 19412183 | We show here that CTL immunodominance in regions of the human immunodeficiency virus type 1 group-associated antigen proteins p17 and p24 correlated with epitope abundance, which was strongly influenced by proteasomal digestion profiles, affinity for the transporter protein TAP, and trimming mediated by the endoplasmatic reticulum aminopeptidase ERAAP, and was moderately influenced by HLA affinity. |
| 5 | 20347630 | Herein, immunization of L(d) mice with HF10 (HPGSVNEFDF) with palmitic acid moieties or a monophosphoryl lipid A derivative elicited potent IFN-gamma production from L(d)-restricted CD8(+) T cells in vitro and protected mice. |
| 6 | 20347630 | Since peptide repertoire presented by MHC class I molecules to CD8(+) T cells is shaped by endoplasmic reticulum-associated aminopeptidase (ERAAP), polymorphisms in the human ERAAP gene ERAP1 were studied and associate with susceptibility to human congenital toxoplasmosis (p<0.05). |