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Gene Information
Gene symbol: EREG
Gene name: epiregulin
HGNC ID: 3443
Synonyms: ER
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AREG | 1 hits |
| 2 | EGF | 1 hits |
| 3 | EGFR | 1 hits |
| 4 | EGR1 | 1 hits |
| 5 | HBEGF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20190820 | Mutant p53 initiates a feedback loop that involves Egr-1/EGF receptor/ERK in prostate cancer cells. |
| 2 | 20190820 | This study shows that in prostate cell lines in culture, Egr-1 overexpression correlated with an alteration of p53 activity because of the expression of SV40 large T-antigen or because of a mutation in the TP53 gene. |
| 3 | 20190820 | In cells containing altered p53 activity, Egr-1 expression was abolished by pharmacological inhibition or RNAi silencing of p53. |
| 4 | 20190820 | Although forced expression of wild-type p53 was not sufficient to trigger Egr-1 transcription, four different mutants of p53 were shown to induce Egr-1. |
| 5 | 20190820 | Direct binding of p53 to the EGR1 promoter could not be detected. |
| 6 | 20190820 | Instead, Egr-1 transcription was driven by the ERK1/2 pathway, as it was abrogated by specific inhibitors of MEK. |
| 7 | 20190820 | Egr-1 increased the transcription of HB-EGF (epidermal growth factor), amphiregulin and epiregulin, resulting in autocrine activation of the EGF receptor (EGFR) and downstream MEK/ERK cascade. |
| 8 | 20190820 | Thus, mutant p53 initiates a feedback loop that involves ERK1/2-mediated transactivation of Egr-1, which in turn increases the secretion of EGFR ligands and stimulates the EGFR signaling pathway. |
| 9 | 20190820 | Finally, p53 may further regulate this feedback loop by altering the level of EGFR expression. |