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Gene Information
Gene symbol: ESRRB
Gene name: estrogen-related receptor beta
HGNC ID: 3473
Synonyms: ERR2, ERRbeta, NR3B2, ERRb
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IL17A | 1 hits |
| 2 | IL17D | 1 hits |
| 3 | PIM1 | 1 hits |
| 4 | RARA | 1 hits |
| 5 | STAT3 | 1 hits |
| 6 | TBX21 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 23333555 | We show that CD4+ and CD8+ Teffector/memory (T(EM)) and other subsets produce IL-17A following SEB stimulation. |
| 2 | 23333555 | We also show that IL-17A is co-produced with other pro-inflammatory cytokines (i.e., IL-2, IFN-γ and TNF-α). |
| 3 | 23333555 | Multifunctional IL-17A producing cells possess markers typical of the T(H)17/T(C)17 and T(H)1 subsets, including CCR6, IL-22, and transcription factors retinoic acid receptor-related orphan nuclear receptor (ROR)-γt and T-bet. |
| 4 | 23886112 | These approaches have included: (1) the use of IL-17A and IL-17F-deficient mice, (2) specific antibodies directed against IL-17, (3) an IL-17 vaccine, (4) methods to block the IL-17 receptor and (5) small-molecule inhibitors of IL-17. |
| 5 | 23886112 | This paper will review the preclinical results using various pharmacological approaches [specific IL-17 antibodies, an IL-17 receptor fusion protein, IL-12/IL-23 p40 subunit and IL-17 vaccine approaches, as well as a small molecule inhibitor (Vidofludimus)] to inhibit IL-17 in animal models of IBD. |
| 6 | 23886112 | Finally, future pharmacological approaches of interest will be discussed, such as: (1) Retinoic acid receptor-related orphan nuclear receptor gamma t (Rorγt) antagonists, (2) Retinoic acid receptor alpha (RARα) antagonists, (3) Pim-1 kinase inhibitors and (4) Dual small-molecule inhibitors of NF-κB and STAT3, like synthetic triterpenoids. |