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Gene Information
Gene symbol: F12
Gene name: coagulation factor XII (Hageman factor)
HGNC ID: 3530
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | HABP2 | 1 hits |
| 2 | HMHA1 | 1 hits |
| 3 | KRT31 | 1 hits |
| 4 | PLG | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7327427 | Toxic granulomas produced by metals may be caused by C3 being split by plasmin after conversion from plasminogen by activation of the Hageman factor. |
| 2 | 16153533 | The hyaluronan-binding protease upregulates ERK1/2 and PI3K/Akt signalling pathways in fibroblasts and stimulates cell proliferation and migration. |
| 3 | 16153533 | The hyaluronan-binding protease (HABP) is a serine protease in human plasma which is structurally related to plasminogen activators, coagulation factor XII and hepathocyte growth factor activator. |
| 4 | 16153533 | It can in vitro activate the coagulation factor FVII, kininogen and plasminogen activators. |
| 5 | 16153533 | Treatment of lung fibroblasts with HABP lead to a rapid activation of signalling pathways, including the mitogen-activated protein kinase (MAPK) pathway with c-Raf, MEK and ERK1/2. |
| 6 | 16153533 | Additionally the activation of the PI3K/Akt pathway and of several translation-related proteins was found. |
| 7 | 16153533 | Stimulation of signalling and proliferation by HABP involved the fibroblast growth factor receptor 1 (FGFR-1). |
| 8 | 16153533 | HABP-stimulated proliferation of lung fibroblasts MRC-5 was accompanied by a significant intracellular increase in basic fibroblast growth factor (bFGF), the major ligand of FGFR-1; bFGF could however not be identified in the supernatant of HABP-treated cells. |
| 9 | 21110118 | In this study, highly pure recombinant proteins generated using baculovirus expression vector system based on full-length of HA (HAF) and antigenic region of HA(1) genes of H9 subtype, and also inactivated whole virus were used to immunization of chickens. |
| 10 | 21110118 | Relative to the conventional method using whole virus immunization and recombinant HAF protein, the antiserum prepared by recombinant HA(1) had a specificity of 100% for all tested subtypes. |
| 11 | 21110118 | In this study, highly pure recombinant proteins generated using baculovirus expression vector system based on full-length of HA (HAF) and antigenic region of HA(1) genes of H9 subtype, and also inactivated whole virus were used to immunization of chickens. |
| 12 | 21110118 | Relative to the conventional method using whole virus immunization and recombinant HAF protein, the antiserum prepared by recombinant HA(1) had a specificity of 100% for all tested subtypes. |