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Gene Information
Gene symbol: F9
Gene name: coagulation factor IX
HGNC ID: 3551
Synonyms: FIX
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | F8 | 1 hits |
| 2 | IFNG | 1 hits |
| 3 | IRF9 | 1 hits |
| 4 | STAT1 | 1 hits |
| 5 | STAT2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 1826737 | Treatment with FVIII or FIX concentrate did not influence the antibody response in the patients. |
| 2 | 20739522 | Porcine reproductive and respiratory syndrome virus inhibits type I interferon signaling by blocking STAT1/STAT2 nuclear translocation. |
| 3 | 20739522 | The transcript levels of IFN-stimulated genes ISG15 and ISG56 and protein level of signal transducer and activator of transcription 2 (STAT2) in PRRSV VR2385-infected MARC-145 cells were significantly lower than those in mock-infected cells after IFN-α treatment. |
| 4 | 20739522 | IFN-induced phosphorylation of both STAT1 and STAT2 and their heterodimer formation in the PRRSV-infected cells were not affected. |
| 5 | 20739522 | However, the majority of the STAT1/STAT2/IRF9 (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked. |
| 6 | 20739522 | Overexpression of NSP1β of PRRSV VR2385 inhibited expression of ISG15 and ISG56 and blocked nuclear translocation of STAT1, which suggests that NSP1β might be the viral protein responsible for the inhibition of IFN signaling. |
| 7 | 20739522 | These findings suggest that PRRSV interferes with the activation and signaling pathway of type I IFNs by blocking ISG factor 3 (ISGF3) nuclear translocation. |
| 8 | 26019270 | IFNs, which transduce pivotal signals through Stat1 and Stat2, effectively suppress the replication of Legionella pneumophila in primary murine macrophages. |
| 9 | 26019270 | New studies demonstrating that the robust response to IFN-αβ is lost in Stat1-Stat2 double-knockout macrophages suggest that Stat1 and Stat2 are functionally redundant in their ability to direct an innate response toward L. pneumophila. |
| 10 | 26019270 | Because the ability of IFN-αβ to signal through Stat1-dependent complexes (i.e., Stat1-Stat1 and Stat1-Stat2 dimers) has been well characterized, the current studies focus on how Stat2 is able to direct a potent response to IFN-αβ in the absence of Stat1. |
| 11 | 26019270 | These studies reveal that IFN-αβ is able to drive the formation of a Stat2 and IFN regulatory factor 9 complex that drives the expression of a subset of IFN-stimulated genes, but with substantially delayed kinetics. |