Ignet

Gene Information

Gene symbol: FADD

Gene name: Fas (TNFRSF6)-associated via death domain

HGNC ID: 3573

Synonyms: MORT1, GIG3

Related Genes

#	Gene Symbol	Number of hits
1	CASP10	1 hits
2	CASP8	1 hits
3	CD40	1 hits
4	CD40LG	1 hits
5	CFLAR	1 hits
6	CRMP1	1 hits
7	FAS	1 hits
8	IL4	1 hits
9	KRR1	1 hits
10	MLKL	1 hits
11	NLRP3	1 hits
12	RIPK1	1 hits
13	RIPK3	1 hits
14	TICAM1	1 hits
15	TRADD	1 hits

Related Sentences

#	PMID	Sentence
1	17378240	CD40L and IL-4 stimulation of acute lymphoblastic leukemia cells results in upregulation of mRNA level of FLICE--an important component of apoptosis.
2	17378240	Since it is still unclear whether CD40 ligation drives neoplastic B-cells to apoptosis or not, we assessed the mRNA expression of FLICE, FAS, FADD and TRADD - important components of apoptosis machinery, using real-time PCR in acute lymphoblastic leukemia cells before and after CD40 and IL-4 stimulation.
3	17378240	ALL cells stimulated with CD40L/IL-4 expressed dendritic cell phenotype at mRNA and protein levels (upregulation of main costimulatory and adhesion molecules noted in real-time RT PCR and flow cytometry); they also expressed higher amounts of mRNA for FLICE, TRADD and FADD after CD40L/IL-4 stimulation.
4	17378240	However differences statistically significant comparing cells cultured with CD40L/IL-4 and medium alone regarded only FLICE.
5	17378240	CD40L and IL-4 stimulation of acute lymphoblastic leukemia cells results in upregulation of mRNA level of FLICE--an important component of apoptosis.
6	17378240	Since it is still unclear whether CD40 ligation drives neoplastic B-cells to apoptosis or not, we assessed the mRNA expression of FLICE, FAS, FADD and TRADD - important components of apoptosis machinery, using real-time PCR in acute lymphoblastic leukemia cells before and after CD40 and IL-4 stimulation.
7	17378240	ALL cells stimulated with CD40L/IL-4 expressed dendritic cell phenotype at mRNA and protein levels (upregulation of main costimulatory and adhesion molecules noted in real-time RT PCR and flow cytometry); they also expressed higher amounts of mRNA for FLICE, TRADD and FADD after CD40L/IL-4 stimulation.
8	17378240	However differences statistically significant comparing cells cultured with CD40L/IL-4 and medium alone regarded only FLICE.
9	22193709	Pathogens specifically target both the caspase 8-dependent apoptotic cell death pathway and the necrotic cell death pathway that is dependent on receptor-interacting protein 1 (RIP1; also known as RIPK1) and RIP3 (also known as RIPK3).
10	22193709	The fundamental co-regulation of these two cell death pathways emerged when the midgestational death of mice deficient in FAS-associated death domain protein (FADD) or caspase 8 was reversed by elimination of RIP1 or RIP3, indicating a far more entwined relationship than previously appreciated.
11	22193709	Thus, mammals require caspase 8 activity during embryogenesis to suppress the kinases RIP1 and RIP3 as part of the dialogue between two distinct cell death processes that together fulfil reinforcing roles in the host defence against intracellular pathogens such as herpesviruses.
12	25807052	Whereas Fas or FasL knockout mice had improved CMI, down-regulation of Fas or FasL by shRNA or antibody failed to improve CMI and was accompanied by increases in regulatory T cells (Treg).
13	25807052	The adjuvant effects of Fas-associated death domain (FADD) and of cellular FLICE-inhibitory protein (cFLIP) were consistently accompanied by increased effector memory T lymphocytes and increased T cell proliferation.
14	25807052	However, half of the mice pre-electroporated with FADD or cFLIP plasmids were able to clear LCMV-Clone 13 by day nine, and, in the case of cFLIP, increased viral clearance was accompanied by higher CMI.
15	25807052	Whereas Fas or FasL knockout mice had improved CMI, down-regulation of Fas or FasL by shRNA or antibody failed to improve CMI and was accompanied by increases in regulatory T cells (Treg).
16	25807052	The adjuvant effects of Fas-associated death domain (FADD) and of cellular FLICE-inhibitory protein (cFLIP) were consistently accompanied by increased effector memory T lymphocytes and increased T cell proliferation.
17	25807052	However, half of the mice pre-electroporated with FADD or cFLIP plasmids were able to clear LCMV-Clone 13 by day nine, and, in the case of cFLIP, increased viral clearance was accompanied by higher CMI.
18	26104484	Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3.
19	26104484	Both pathways require the scaffolding but not the catalytic function of caspase-8 or RIPK1.
20	26104484	Only the late pathway requires kinase competent RIPK3 and MLKL function.
21	26104484	Mechanistically, FADD/caspase-8 scaffolding function provides a post-translational signal 1 in the intermediate pathway, whereas in the late pathway it helps the oligomerization of RIPK3, which together with MLKL provides both signal 1 and 2 for inflammasome assembly.
22	26104484	Cytoplasmic dsRNA activates NLRP3 independent of TRIF, RIPK1, RIPK3 or mitochondrial DRP1, but requires FADD/caspase-8 in wildtype macrophages to remove RIPK3 inhibition.
23	26104484	Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3.
24	26104484	Both pathways require the scaffolding but not the catalytic function of caspase-8 or RIPK1.
25	26104484	Only the late pathway requires kinase competent RIPK3 and MLKL function.
26	26104484	Mechanistically, FADD/caspase-8 scaffolding function provides a post-translational signal 1 in the intermediate pathway, whereas in the late pathway it helps the oligomerization of RIPK3, which together with MLKL provides both signal 1 and 2 for inflammasome assembly.
27	26104484	Cytoplasmic dsRNA activates NLRP3 independent of TRIF, RIPK1, RIPK3 or mitochondrial DRP1, but requires FADD/caspase-8 in wildtype macrophages to remove RIPK3 inhibition.