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Gene Information
Gene symbol: FAM134C
Gene name:
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | DUSP3 | 1 hits |
| 2 | PSME3 | 1 hits |
| 3 | SLC4A1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 24901344 | Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis. |
| 2 | 24901344 | Of these 422 genes, whole genome transcription profiling identified five genes (Dcaf7, Dusp3, Fam134c, Psme3, and Slc4a1) that were significantly differentially expressed in a) S. aureus -infected susceptible (A/J) vs. resistant (C57BL/6J) mice and b) humans with S. aureus blood stream infection vs. healthy subjects. |
| 3 | 24901344 | Three of these genes (Dcaf7, Dusp3, and Psme3) were down-regulated in susceptible vs. resistant mice at both pre- and post-infection time points by qPCR. siRNA-mediated knockdown of Dusp3 and Psme3 induced significant increases of cytokine production in S. aureus-challenged RAW264.7 macrophages and bone marrow derived macrophages (BMDMs) through enhancing NF-κB signaling activity. |
| 4 | 24901344 | These findings suggest that Dusp3 and Psme3 contribute to S. aureus infection susceptibility in A/J mice and play a role in human S. aureus infection. |