Ignet

Gene Information

Gene symbol: FCGRT

Gene name: Fc fragment of IgG, receptor, transporter, alpha

HGNC ID: 3621

Synonyms: FCRN, alpha-chain

Related Genes

#	Gene Symbol	Number of hits
1	ALB	1 hits
2	CD4	1 hits
3	FCAMR	1 hits
4	PIGR	1 hits

Related Sentences

#	PMID	Sentence
1	12850341	Transfer across the syncytiotrophoblast of the chorionic villi is mediated by the neonatal Fc receptor, FcRn.
2	15888731	RT-PCR showed that Fcgrt (neonatal Fc receptor, also known as FcRn) is expressed in the reproductive ducts, where IgG is probably transported across epithelium, being particularly strong in the ductuli efferentes (where most IgG was reabsorbed) and distal caput epididymidis.
3	17878945	However, experimental evidence suggests that other host receptors, such as hyaluronic acid (HA) and the neonatal Fc receptor, may also support placental binding.
4	21240266	Efficient mucosal vaccination mediated by the neonatal Fc receptor.
5	21240266	The neonatal Fc receptor (FcRn) mediates the transport of IgG across polarized epithelial cells lining mucosal surfaces.
6	21240266	Efficient mucosal vaccination mediated by the neonatal Fc receptor.
7	21240266	The neonatal Fc receptor (FcRn) mediates the transport of IgG across polarized epithelial cells lining mucosal surfaces.
8	21849464	A neonatal Fc receptor-targeted mucosal vaccine strategy effectively induces HIV-1 antigen-specific immunity to genital infection.
9	21849464	Given the role of neonatal Fc receptor (FcRn) in transferring IgG across polarized epithelial cells which line mucosal surfaces, FcRn might be useful for delivering HIV vaccine antigens across mucosal epithelial barriers to the underlying antigen-presenting cells.
10	21849464	A neonatal Fc receptor-targeted mucosal vaccine strategy effectively induces HIV-1 antigen-specific immunity to genital infection.
11	21849464	Given the role of neonatal Fc receptor (FcRn) in transferring IgG across polarized epithelial cells which line mucosal surfaces, FcRn might be useful for delivering HIV vaccine antigens across mucosal epithelial barriers to the underlying antigen-presenting cells.
12	24745789	When compared to small molecules (SMs), they have different physicochemical properties and demonstrate unique and complex pharmacokinetic (PK) characteristics that are dependent on several factors such as net charge, neonatal Fc receptor [FcRn], Fcγ receptor [FcγR], glycosylation, PEGylation or aggregation.
13	25119033	Enhanced neonatal Fc receptor function improves protection against primate SHIV infection.
14	25119033	The localization and persistence of antibodies at these sites is influenced by the neonatal Fc receptor (FcRn), whose role in protecting against infection in vivo has not been defined.
15	25119033	A bnAb directed to the CD4-binding site of the HIV-1 envelope (Env) protein (denoted VRC01) was modified by site-directed mutagenesis to increase its binding affinity for FcRn.
16	25119033	Enhanced neonatal Fc receptor function improves protection against primate SHIV infection.
17	25119033	The localization and persistence of antibodies at these sites is influenced by the neonatal Fc receptor (FcRn), whose role in protecting against infection in vivo has not been defined.
18	25119033	A bnAb directed to the CD4-binding site of the HIV-1 envelope (Env) protein (denoted VRC01) was modified by site-directed mutagenesis to increase its binding affinity for FcRn.
19	25119033	Enhanced neonatal Fc receptor function improves protection against primate SHIV infection.
20	25119033	The localization and persistence of antibodies at these sites is influenced by the neonatal Fc receptor (FcRn), whose role in protecting against infection in vivo has not been defined.
21	25119033	A bnAb directed to the CD4-binding site of the HIV-1 envelope (Env) protein (denoted VRC01) was modified by site-directed mutagenesis to increase its binding affinity for FcRn.
22	25703189	The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy.
23	25703189	This arises from IgG interaction with the neonatal Fc receptor, FcRn.
24	25703189	FcRn is the central regulator of IgG and albumin homeostasis throughout life and is increasingly being recognized as an important player in autoimmune disease, mucosal immunity, and tumor immune surveillance.
25	25703189	The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy.
26	25703189	This arises from IgG interaction with the neonatal Fc receptor, FcRn.
27	25703189	FcRn is the central regulator of IgG and albumin homeostasis throughout life and is increasingly being recognized as an important player in autoimmune disease, mucosal immunity, and tumor immune surveillance.
28	25703189	The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy.
29	25703189	This arises from IgG interaction with the neonatal Fc receptor, FcRn.
30	25703189	FcRn is the central regulator of IgG and albumin homeostasis throughout life and is increasingly being recognized as an important player in autoimmune disease, mucosal immunity, and tumor immune surveillance.
31	25756612	Passive transfer of immune serum completely protected wild-type, but not Fcγ-receptor or neonatal Fc-receptor knock-out mice.
32	25912958	Finally, we show that this biosynthetic nanoparticle can be engineered to enhance interactions with the human neonatal Fc receptor (FcRn) without loss of the oligomeric structure, a crucial modification for these molecules in therapy and/or vaccine strategies where a long plasma half-life is critical.
33	25948883	Mechanisms by which the newborn piglet gut facilitates uptake of colostral cells, antibodies, and proteins may include FcRn and pIgR receptor-mediated endocytosis and paracellular transport between tight junctions (TJs).