Ignet

Gene Information

Gene symbol: GADD45B

Gene name: growth arrest and DNA-damage-inducible, beta

HGNC ID: 4096

Synonyms: GADD45BETA, DKFZP566B133

Related Genes

#	Gene Symbol	Number of hits
1	BCL2A1	1 hits
2	CASP2	1 hits
3	CASP8	1 hits
4	CAST	1 hits
5	CCL4	1 hits
6	CDK2	1 hits
7	CFLAR	1 hits
8	IL1B	1 hits
9	IL6	1 hits
10	MYD88	1 hits
11	NFKB1	1 hits
12	NFKB2	1 hits
13	PIM2	1 hits
14	RELA	1 hits
15	SOD2	1 hits
16	TLR4	1 hits
17	TNF	1 hits
18	TNFAIP3	1 hits
19	TNFRSF10C	1 hits
20	TNFRSF10D	1 hits
21	TNFSF10	1 hits
22	VEGFA	1 hits
23	XIAP	1 hits

Related Sentences

#	PMID	Sentence
1	22986450	Specific targets in this category included genes asso-ciated with the intrinsic and extrinsic apoptotic pathways (CFLAR, TNFAIP3, TNFRSF10D, SOD2, BCL2A1, BIRC4, PIM2, TNFSF10, TNFRSF10C, CASP2 and CASP8) and genes that act via the NFĸB pathway and other mechanisms to prolong cell viability (NFKB1, NFKB2 and RELA, IL1B, CAST, CDK2,GADD45B, BCL3, BIRC3, CDK2, IL1A, PBEF1, IL6, CXCL1, CCL4 and VEGF).
2	22986450	Moreover, we demonstrate that the X-linked inhibitor of apoptosis protein remained abundant in polymorphonuclear leukocytes over 48 h of LVS infection, whereas BAX mRNA and protein were progressively downregulated.
3	25479797	Modulation of the NAS process represents a path toward the development of novel vaccines or drugs, through targets such as myeloid differentiation primary-response protein 88 (MyD88) and tumor necrosis factor (TNF) receptor-associated factor (TRAF) 3 and 6 in Toll-like receptor (TLR)-mediated signaling pathways.
4	25540284	Secretion of IL-6, RANTES (CCL5) and IP-10 (CXCL10) were assessed by ELISA.
5	25540284	MPLA alone was a weak stimulator of myeloid differentiation primary response protein 88-dependent IL-6 and did not induce TIR-domain-containing adapter-inducing IFN-β (TRIF)-dependent chemokine responses.
6	25540284	MPLA significantly reduced LPS-mediated IL-6 production.
7	25540284	This inhibitory effect was also conferred for the TRIF-dependent chemokines RANTES and IP-10.
8	26090808	Moreover, in vivo administration of GB promoted up-regulation of CD86, MHC class I and MHC class II and production of IL-6, IL-12 and TNF-α in spleen DCs.
9	26090808	Furthermore, Toll like receptor 4 (TLR4) and myeloid differentiation primary response 88 (MyD88) signaling pathway were essential for DC activation induced by GB.
10	26090808	In addition, GB strongly prompted the proliferation of ovalbumin (OVA)-specific CD4 and CD8 T cells.