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Gene Information
Gene symbol: GNRHR
Gene name: gonadotropin-releasing hormone receptor
HGNC ID: 4421
Synonyms: LHRHR
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AR | 1 hits |
| 2 | ESR1 | 1 hits |
| 3 | GNRH1 | 1 hits |
| 4 | KISS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12810583 | Antibodies were affinity purified and shown by ELISA to be selective for mammalian GnRH compared with GnRH II and [Gln(8)]GnRH. |
| 2 | 12810583 | The purified anti-GnRH antibodies inhibited GnRH-stimulated signal transduction in COS-1 cells expressing the human GnRH receptor. |
| 3 | 24576399 | At 24wk after the primary immunisation, testes were severely atrophied, spermatogenesis was arrested and steroidogenesis was suppressed, as evidenced by lesser amounts of testicular cholesterol side-chain cleavage cytochrome P-450 and 17α-hydroxylase cytochrome P-450 mRNA (P<0.05). |
| 4 | 24576399 | Furthermore, the amounts of mRNA for GnRH in the arcuate nucleus (Arc), of the hypothalamus and GnRH receptor and LH-β in the pituitary and genes in sex-hormone negative feedback loops (androgen receptor, oestrogen alpha receptor, kisspeptin encoded gene and kisspeptin receptor) in the Arc were decreased in pregnenolone-immunised rabbits compared to controls (P<0.05). |
| 5 | 24906938 | Compared with controls, antitestosterone immunization triggered: a substantial and sustained antibody response (P < 0.01); increases in serum concentrations of luteinizing hormone (LH) and testosterone and testis weight and volume (P < 0.05); hyperplasia of testicular interstitial tissue with clustered and hypertrophic Leydig cells; and greater (P < 0.05) enzyme protein and messenger RNA (mRNA) expression levels for testicular cholesterol side-chain cleavage cytochrome P-450, 17α-hydroxylase cytochrome P-450, and 3β-dydroxysteroid dehydrogenase. |
| 6 | 24906938 | Furthermore, immunoneutralization of testosterone upregulated mRNA expressions for genes in sex steroid negative feedback loops, including androgen receptor (AR), estrogen receptor alpha (ER-α), kisspeptin encoded gene (kiss-1) and kisspeptin receptor (G-coupled receptor 54) and gonadotropin-releasing hormone (GnRH) in the hypothalamic arcuate nucleus, GnRH receptor and LH-β in pituitary, and AR, inhibin-α and βA subunits in testes (P < 0.05). |