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Gene Information
Gene symbol: GPR15
Gene name:
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AGTRL1 | 1 hits |
| 2 | CCR3 | 1 hits |
| 3 | CCR5 | 1 hits |
| 4 | CCR8 | 1 hits |
| 5 | CXCR6 | 1 hits |
| 6 | FPR2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11242524 | Cloning and sequencing of cynomolgus macaque CCR3, GPR15, and STRL33: potential coreceptors for HIV type 1, HIV type 2, and SIV. |
| 2 | 11242524 | However, since it is known that minor species-specific sequence changes in CCR3 and STRL33 affect their ability to act as coreceptors for HIV-1, HIV-2, and/or SIV, it is important to ascertain whether the relevant receptors function as expected in the animal model of choice. |
| 3 | 11242524 | The sequence of three cynomolgus macaque receptors, CCR3, GPR15, and STRL33, are presented in this sequence note. |
| 4 | 11242524 | Cloning and sequencing of cynomolgus macaque CCR3, GPR15, and STRL33: potential coreceptors for HIV type 1, HIV type 2, and SIV. |
| 5 | 11242524 | However, since it is known that minor species-specific sequence changes in CCR3 and STRL33 affect their ability to act as coreceptors for HIV-1, HIV-2, and/or SIV, it is important to ascertain whether the relevant receptors function as expected in the animal model of choice. |
| 6 | 11242524 | The sequence of three cynomolgus macaque receptors, CCR3, GPR15, and STRL33, are presented in this sequence note. |
| 7 | 14581570 | Nine Envs used CCR5 as a coreceptor, one used CXCR4, and two used both CCR5 and CXCR4 in cell-to-cell fusion assays. |
| 8 | 14581570 | Eight Envs could also use CCR3, CCR8, GPR15, STRL33, Apj, and/or GPR1, but these coreceptors did not play a major role in virus entry into microglia. |
| 9 | 21835785 | The great majority of human immunodeficiency virus type 1 (HIV-1) strains enter CD4+ target cells by interacting with one of two coreceptors, CCR5 or CXCR4. |
| 10 | 21835785 | Here we describe a transmitted/founder (T/F) virus (ZP6248) that was profoundly impaired in its ability to utilize CCR5 and CXCR4 coreceptors on multiple CD4+ cell lines as well as primary human CD4+ T cells and macrophages in vitro yet replicated to very high titers (>80 million RNA copies/ml) in an acutely infected individual. |
| 11 | 21835785 | The ZP6248 T/F virus could also infect cell lines overexpressing the alternative coreceptors GPR15, APJ, and FPRL-1. |
| 12 | 21835785 | These results suggest that the ZP6248 T/F virus established an acute in vivo infection by using coreceptor(s) other than CCR5 or CXCR4 or that the CCR5 coreceptor existed in an unusual conformation in this individual. |
| 13 | 24897520 | However, we recently identified a transmitted/founder (T/F) virus (ZP6248) that efficiently used an alternative coreceptor GPR15, rather than commonly used CXCR4 and CCR5, to establish clinical infection. |
| 14 | 24897520 | These results demonstrated that amino acids in ZP6248 V3 might form a unique conformation that was critical for the interaction with GPR15 while the amino acids at position 314 in the V3 crown of ZP6248 played a key role in interaction with both CCR5 and GPR15. |