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Gene Information
Gene symbol: GPRC5C
Gene name: G protein-coupled receptor, family C, group 5, member C
HGNC ID: 13309
Synonyms: RAIG-3
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CXCR7 | 1 hits |
| 2 | NRN1 | 1 hits |
| 3 | POU4F1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15958552 | When expression of a panel of KSHV-induced cellular transcripts was inhibited with antisense oligomers, we observed inhibition of DMVEC proliferation and foci formation using antisense molecules to RDC1 and Neuritin. |
| 2 | 15958552 | We further showed that transformation of KSHV-infected DMVEC was inhibited by small interfering RNA directed at RDC1 or Neuritin. |
| 3 | 15958552 | Ectopic expression of Neuritin in NIH 3T3 cells resulted in changes in cell morphology and anchorage-independent growth, whereas RDC1 ectopic expression significantly increased cell proliferation. |
| 4 | 15958552 | In addition, both RDC1- and Neuritin-expressing cells formed tumors in nude mice. |
| 5 | 15958552 | RDC1 is an orphan G protein-coupled receptor, whereas Neuritin is a growth-promoting protein known to mediate neurite outgrowth. |
| 6 | 15958552 | Our data suggest that KSHV-mediated transformation involves exploitation of the hitherto unrealized oncogenic properties of RDC1 and Neuritin. |