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Gene Information
Gene symbol: GRB2
Gene name: growth factor receptor-bound protein 2
HGNC ID: 4566
Synonyms: NCKAP2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | PDE4A | 1 hits |
| 2 | VAV1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21042712 | Herein we describe T cell costimulation via CD25, the interleukin (IL)-2 receptor, during priming of naive T cells with a tumor vaccine. |
| 2 | 21042712 | To this end, we produced, purified and characterized the fusion protein bsHN-IL2 which contains the IL-2 cytokine and an antibody scFv fragment directed towards the Hemagglutinin-Neuraminidase (HN) protein of Newcastle Disease Virus (NDV). |
| 3 | 21042712 | In the presence of CD3-mediated signal 1, the vaccine/bsHN-IL2 provided via CD25 a strong bystander antitumor effect in vitro leading to tumor growth inhibition, even stronger than the vaccine/bsHN-CD28 which provides costimulation via CD28. |
| 4 | 21042712 | Transcriptome analysis of naive T cells which were stimulated with the vaccine/bsHN-IL2 showed, similarly to the vaccine/bsHN-CD28, upregulation of 71 genes belonging to different signalling pathways, including PLC-γ1, Grb-2, Vav-1 and PDE-4A. |